Sahnoun Dhouha, Agrebi Myriam, Dridi Bahaeddine, Zayani Hanen, Boughamoura Lamia, Ben Salem Chaker
Department of Clinical Pharmacology (DS, MA, BD, CBS), Faculty of Medicine, Sousse, Tunisia.
Department of Cardiology (HZ), Sahloul Hospital, Sousse, Tunisia.
J Pediatr Pharmacol Ther. 2025 Jun;30(3):372-375. doi: 10.5863/JPPT-24-00015. Epub 2025 Jun 9.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially life-threatening syndrome. Herein, we present the case of a 14-year-old female who developed a diffuse erythematous rash with fever and facial edema 6 weeks after initiating treatment with carbamazepine and sertraline. Laboratory tests showed an inflammatory reaction, elevated liver enzymes, and mild eosinophilia. Serology tests were negative for viral hepatitis, cytomegalovirus, herpes simplex virus, and parvovirus B19, but positive anti-VCA IgM and anti-EBNA IgG confirmed the presence of Epstein-Barr virus reactivation. Drugs were withdrawn, and the patient was treated with corticosteroid. Carbamazepine was identified as the culprit drug after performing patch tests. Even though DRESS is rare in childhood, we present another case of carbamazepine-induced DRESS in an adolescent associated with EBV activation.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种罕见且可能危及生命的综合征。在此，我们报告一例14岁女性病例，该患者在开始使用卡马西平和舍曲林治疗6周后出现弥漫性红斑疹伴发热和面部水肿。实验室检查显示有炎症反应、肝酶升高和轻度嗜酸性粒细胞增多。血清学检查对病毒性肝炎、巨细胞病毒、单纯疱疹病毒和细小病毒B19均为阴性，但抗VCA IgM和抗EBNA IgG阳性证实存在EB病毒再激活。停用药物，患者接受了皮质类固醇治疗。进行斑贴试验后确定卡马西平为致病药物。尽管DRESS在儿童期罕见，但我们报告了另一例青少年卡马西平诱发的DRESS病例，该病例与EBV激活有关。
