Khuntia Hemant Kumar, Manna Prabir, Barik Deepak Kumar, Biswas Subhojeet, Bramha Prasanta Kumar, Pati Sanghamitra, Ranjit Manoranjan, Bal Madhusmita, Kerketta Anna Salomi
Institute of Veterinary Science and Animal Husbandry, Department of Microbiology, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India.
Indian Council of Medical Research (ICMR)-Regional Medical Research Centre, Bhubaneswar, Odisha, India.
Front Microbiol. 2025 Jun 4;16:1470783. doi: 10.3389/fmicb.2025.1470783. eCollection 2025.
Enterotoxigenic (ETEC), producing heat-stable (ST) and/or heat-labile (LT) enterotoxins, is a major cause of diarrhea in children and travelers in developing countries. Surveillance in cholera-endemic regions is crucial for timely public health response.
Between May and November 2022, a cross-sectional study was conducted in Puri, India. Rectal swabs from 256 hospitalized diarrhea patients were analyzed for diarrheagenic and using microbiological and molecular methods. Antimicrobial susceptibility of ETEC isolates was also assessed.
ETEC was detected in 20.3% of cases, making it the most prevalent pathogen. No Vibrio cholerae was isolated. EAEC and EPEC were identified in 6.2% and 2.3% of cases, respectively. ETEC was significantly more common in children under 2 years ( < 0.00001), though overall age correlation was weak ( = -0.013). Symptoms included watery stool, vomiting, abdominal pain, and dehydration, with dehydration significantly associated with adults ( < 0.05). ETEC strains were susceptible to streptomycin, chloramphenicol, gentamicin, and amikacin.
ETEC has emerged as the dominant diarrheal pathogen in a cholera-endemic area, posing a risk to both children and adults. These findings highlight the need for continued epidemiological monitoring and age-targeted interventions.
产毒性大肠杆菌（ETEC）可产生耐热（ST）和/或不耐热（LT）肠毒素，是发展中国家儿童和旅行者腹泻的主要原因。在霍乱流行地区进行监测对于及时做出公共卫生反应至关重要。
2022年5月至11月期间，在印度普里进行了一项横断面研究。采用微生物学和分子方法，对256例住院腹泻患者的直肠拭子进行致泻性分析，并评估ETEC分离株的抗菌药敏性。
20.3%的病例检测到ETEC，使其成为最常见的病原体。未分离到霍乱弧菌。分别在6.2%和2.3%的病例中鉴定出EAEC和EPEC。ETEC在2岁以下儿童中明显更常见（<0.00001），尽管总体年龄相关性较弱（=-0.013）。症状包括水样便、呕吐、腹痛和脱水，脱水在成人中显著相关（<0.05）。ETEC菌株对链霉素、氯霉素、庆大霉素和阿米卡星敏感。
ETEC已成为霍乱流行地区主要的腹泻病原体，对儿童和成人都构成风险。这些发现凸显了持续进行流行病学监测和针对不同年龄进行干预的必要性。
