Jiao Yingying, Chen Xiuru, Liu Lu, Lu Yantong, Gao Minghuang, Wang Qi, Chi Xiaoling, Mo Yousheng
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
Front Nutr. 2025 Jun 4;12:1600927. doi: 10.3389/fnut.2025.1600927. eCollection 2025.
As economy is growing, the number of patients living with obesity has rapidly increased globally. Patients with obesity or diabetes have become a serious global health issue that requires the attention and participation of society as a whole. The ketogenic diet, as an emerging nutritional therapy for improving obesity, takes into consideration the differences between sexes in genetic variation, hormonal balance, and body fat distribution. The aim is to elucidate the effectiveness of sex differences in ketogenic dieting for weight loss and to explore suitable weight loss strategies. In this review, we delve into the physiological sexual differences between men and women in terms of fat and muscle tissue and discuss the sex-specific potential mechanisms underlying the differential effects of the ketogenic diet for weight loss. Based on this foundation, we further propose brief weight loss recommendations beneficial for both men and women. It is hoped that, in this direction, the optimization of short-term or long-term clinical weight loss programs can be developed based on sexes.
随着经济的发展，全球肥胖患者的数量迅速增加。肥胖或糖尿病患者已成为一个严重的全球健康问题，需要全社会的关注和参与。生酮饮食作为一种新兴的改善肥胖的营养疗法，考虑到了男女在基因变异、激素平衡和体脂分布方面的差异。其目的是阐明生酮饮食中性别差异对减肥的有效性，并探索合适的减肥策略。在这篇综述中，我们从脂肪和肌肉组织方面深入探讨了男女之间的生理性差异，并讨论了生酮饮食减肥效果差异背后的性别特异性潜在机制。在此基础上，我们进一步提出了对男女都有益的简要减肥建议。希望能朝着这个方向，根据性别制定短期或长期临床减肥计划的优化方案。
