Gao Qinghe, Lin Zongqi, Zhang Yihua, Cai Jiantong, Li Shaopeng
Department of Urology, Shishi Municipal Hospital, Quanzhou, Fujian, China.
Front Nutr. 2025 Jun 4;12:1610288. doi: 10.3389/fnut.2025.1610288. eCollection 2025.
Prostate cancer (PCa) is associated with obesity, especially visceral fat. WWI may reflect the distribution of body fat more accurately. However, it is unclear whether WWI is associated with the risk of developing PCa.
Seventy thousand one hundred and ninety participants took part in the National Health and Nutrition Examination Survey (NHANES). The associations between WWI and PCa risk were analyzed through multiple regression. The association between WWI and prostate cancer was analyzed in subgroups using stratified factors, with interaction tests performed to evaluate the stability of this association across subgroups. In addition, restricted cubic sample plots and threshold effects were examined to further explore the nonlinear association between WWI and prostate cancer. Finally, subject work characteristics (ROC) curves were used to evaluate the accuracy of different obesity indicators in predicting PCa.
Multiple regression analyses revealed that those individuals with a higher WWI index had a higher prevalence of prostate cancer, while subgroup analyses and interaction tests showed that the correlation between WWI and the prevalence of PCa differed across age groups (interaction < 0.05). The ROC curves showed that the predictive power of WWI for the prevalence of PCa was superior to that of traditional indicators of obesity (both < 0.05).
There was a positive and significant association between PCa risk and WWI, especially in male participants aged <60 years. Further comprehensive studies are required to confirm our findings.
前列腺癌（PCa）与肥胖相关，尤其是内脏脂肪。腰围身高比（WWI）可能更准确地反映身体脂肪分布。然而，尚不清楚WWI是否与PCa发生风险相关。
70190名参与者参加了美国国家健康与营养检查调查（NHANES）。通过多元回归分析WWI与PCa风险之间的关联。使用分层因素在亚组中分析WWI与前列腺癌之间的关联，并进行交互检验以评估该关联在各亚组中的稳定性。此外，检查受限立方样条图和阈值效应以进一步探索WWI与前列腺癌之间的非线性关联。最后，使用受试者工作特征（ROC）曲线评估不同肥胖指标预测PCa的准确性。
多元回归分析显示，WWI指数较高的个体前列腺癌患病率较高，而亚组分析和交互检验表明，WWI与PCa患病率之间的相关性在不同年龄组中存在差异（交互作用<0.05）。ROC曲线显示，WWI对PCa患病率的预测能力优于传统肥胖指标（均<0.05）。
PCa风险与WWI之间存在正相关且显著相关，尤其是在年龄<60岁的男性参与者中。需要进一步的综合研究来证实我们的发现。
