新冠病毒灭活疫苗对中国女性抗苗勒管激素的影响：一项回顾性队列研究
Effect of COVID-19 inactivated vaccine on anti-Müllerian hormone in Chinese women: a retrospective cohort study.
作者信息
Bao Mingjie, Xia Leizhen, Ling Yan, Wen Quan, Shen Xin, Wang Ting, Qian Si, Wang Liqun, Wang Changhua, Peng Shiwei, Zhang Yongping, Zhong Shaoping, Xu Hongying, Zhu Yuan
机构信息
Department of Obstetrics and Gynecology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
Department of Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
出版信息
Front Endocrinol (Lausanne). 2025 Jun 4;16:1403722. doi: 10.3389/fendo.2025.1403722. eCollection 2025.
INTRODUCTION
This study aimed to assess the impact of inactivated COVID-19 vaccine on Anti-Müllerian hormone (AMH) levels in Chinese women.
METHODS
A retrospective analysis was conducted on women aged 18-45 who had undergone two AMH tests between March 2020 and September 2021. Participants were grouped based on vaccine doses (two- and three-dose), time intervals since vaccination, and manufacturers. The difference in AMH levels and the percentage changes in AMH were measured.
RESULTS
The results revealed no significant differences in AMH levels between the vaccinated groups (two- and three-dose) and the control group, both in unadjusted and adjusted analyses. Subgroup analysis showed no statistical difference in either absolute or percentage changes of AMH levels among different time-interval groups and manufacturer groups.
DISCUSSION
In conclusion, the number of doses, time interval, and manufacturer of the inactivated COVID-19 vaccine did not affect AMH levels in Chinese women.
引言
本研究旨在评估新冠病毒灭活疫苗对中国女性抗苗勒管激素（AMH）水平的影响。
方法
对2020年3月至2021年9月期间接受过两次AMH检测的18至45岁女性进行回顾性分析。参与者根据疫苗接种剂量（两剂和三剂）、接种后的时间间隔以及制造商进行分组。测量了AMH水平的差异以及AMH的百分比变化。
结果
结果显示，在未调整和调整分析中，接种组（两剂和三剂）与对照组之间的AMH水平均无显著差异。亚组分析表明，不同时间间隔组和制造商组之间AMH水平的绝对变化或百分比变化均无统计学差异。
讨论
总之，新冠病毒灭活疫苗的接种剂量、时间间隔和制造商对中国女性的AMH水平没有影响。
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