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1例诊断颇具挑战性的典型溶血性尿毒症综合征经依库珠单抗治疗成功治愈

A Diagnostically Challenging Case of Typical Hemolytic Uremic Syndrome Successfully Treated With Eculizumab Therapy.

作者信息

Jha Adarsh, Nader Georgette, Rayamajhi Sumugdha, Hamdan Muhammad

机构信息

Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.

Hematology and Oncology, Sparrow Hospital, Lansing , USA.

出版信息

Cureus. 2025 May 18;17(5):e84362. doi: 10.7759/cureus.84362. eCollection 2025 May.

Abstract

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy that induces microvesicular injury and occlusion and often results in acute renal failure. Atypical HUS is life-threatening and often progresses to end-stage renal disease (ESRD). However, distinguishing between typical and atypical HUS can be challenging due to comorbid conditions and/or laboratory delays. We present a severe case of typical HUS involving a series of complications requiring multidisciplinary care, successfully treated with eculizumab therapy.

摘要

溶血性尿毒症综合征(HUS)是一种血栓性微血管病,可导致微泡损伤和阻塞,常引发急性肾衰竭。非典型HUS危及生命,常进展为终末期肾病(ESRD)。然而,由于合并症和/或实验室检查延误,区分典型和非典型HUS可能具有挑战性。我们报告了一例严重的典型HUS病例,该病例涉及一系列需要多学科护理的并发症,通过依库珠单抗治疗成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7439/12174476/b3cdd36d1361/cureus-0017-00000084362-i01.jpg

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