Jha Adarsh, Nader Georgette, Rayamajhi Sumugdha, Hamdan Muhammad
Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.
Hematology and Oncology, Sparrow Hospital, Lansing , USA.
Cureus. 2025 May 18;17(5):e84362. doi: 10.7759/cureus.84362. eCollection 2025 May.
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy that induces microvesicular injury and occlusion and often results in acute renal failure. Atypical HUS is life-threatening and often progresses to end-stage renal disease (ESRD). However, distinguishing between typical and atypical HUS can be challenging due to comorbid conditions and/or laboratory delays. We present a severe case of typical HUS involving a series of complications requiring multidisciplinary care, successfully treated with eculizumab therapy.
溶血性尿毒症综合征(HUS)是一种血栓性微血管病,可导致微泡损伤和阻塞,常引发急性肾衰竭。非典型HUS危及生命,常进展为终末期肾病(ESRD)。然而,由于合并症和/或实验室检查延误,区分典型和非典型HUS可能具有挑战性。我们报告了一例严重的典型HUS病例,该病例涉及一系列需要多学科护理的并发症,通过依库珠单抗治疗成功治愈。