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1例诊断颇具挑战性的典型溶血性尿毒症综合征经依库珠单抗治疗成功治愈

A Diagnostically Challenging Case of Typical Hemolytic Uremic Syndrome Successfully Treated With Eculizumab Therapy.

作者信息

Jha Adarsh, Nader Georgette, Rayamajhi Sumugdha, Hamdan Muhammad

机构信息

Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.

Hematology and Oncology, Sparrow Hospital, Lansing , USA.

出版信息

Cureus. 2025 May 18;17(5):e84362. doi: 10.7759/cureus.84362. eCollection 2025 May.

DOI:10.7759/cureus.84362
PMID:40535396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12174476/
Abstract

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy that induces microvesicular injury and occlusion and often results in acute renal failure. Atypical HUS is life-threatening and often progresses to end-stage renal disease (ESRD). However, distinguishing between typical and atypical HUS can be challenging due to comorbid conditions and/or laboratory delays. We present a severe case of typical HUS involving a series of complications requiring multidisciplinary care, successfully treated with eculizumab therapy.

摘要

溶血性尿毒症综合征（HUS）是一种血栓性微血管病，可导致微泡损伤和阻塞，常引发急性肾衰竭。非典型HUS危及生命，常进展为终末期肾病（ESRD）。然而，由于合并症和/或实验室检查延误，区分典型和非典型HUS可能具有挑战性。我们报告了一例严重的典型HUS病例，该病例涉及一系列需要多学科护理的并发症，通过依库珠单抗治疗成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7439/12174476/4497fe84e7a8/cureus-0017-00000084362-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7439/12174476/b3cdd36d1361/cureus-0017-00000084362-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7439/12174476/4497fe84e7a8/cureus-0017-00000084362-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7439/12174476/b3cdd36d1361/cureus-0017-00000084362-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7439/12174476/4497fe84e7a8/cureus-0017-00000084362-i02.jpg

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本文引用的文献

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Eculizumab Use in a Temporarily Dialysis-Dependent Patient With Shiga Toxin-Producing Hemolytic Uremic Syndrome With Neurological Complications.依库珠单抗在一名依赖临时透析的产志贺毒素溶血尿毒综合征伴神经系统并发症患者中的应用。
J Pediatr Pharmacol Ther. 2022;27(1):90-95. doi: 10.5863/1551-6776-27.1.90. Epub 2021 Dec 22.
2
High Mortality of HLH in ICU Regardless Etiology or Treatment.无论病因或治疗方法如何，HLH在重症监护病房的死亡率都很高。
Front Med (Lausanne). 2021 Oct 6;8:735796. doi: 10.3389/fmed.2021.735796. eCollection 2021.
3
Epidemiology of Atypical Hemolytic Uremic Syndrome: A Systematic Literature Review.
非典型溶血尿毒综合征的流行病学：一项系统文献综述
Clin Epidemiol. 2020 Mar 12;12:295-305. doi: 10.2147/CLEP.S245642. eCollection 2020.
4
Shiga Toxin-Associated Hemolytic Uremic Syndrome: A Narrative Review.志贺毒素相关性溶血尿毒综合征：一篇叙述性综述。
Toxins (Basel). 2020 Jan 21;12(2):67. doi: 10.3390/toxins12020067.
5
A Case of Hemolytic Uremic Syndrome in a 10-Year-Old Male With Severe Neurologic Involvement Successfully Treated With Eculizumab.10岁男性溶血性尿毒症综合征伴严重神经系统受累病例经依库珠单抗成功治疗
J Investig Med High Impact Case Rep. 2017 Nov 6;5(4):2324709617741144. doi: 10.1177/2324709617741144. eCollection 2017 Oct-Dec.
6
Atypical hemolytic uremic syndrome.非典型溶血性尿毒症综合征
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):217-225. doi: 10.1182/asheducation-2016.1.217.
7
Eculizumab in Typical Hemolytic Uremic Syndrome (HUS) With Neurological Involvement.依库珠单抗治疗伴有神经受累的典型溶血性尿毒症综合征（HUS）
Medicine (Baltimore). 2015 Jun;94(24):e1000. doi: 10.1097/MD.0000000000001000.
8
Atypical hemolytic uremic syndrome.非典型溶血尿毒综合征。
Orphanet J Rare Dis. 2011 Sep 8;6:60. doi: 10.1186/1750-1172-6-60.
9
Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype.遗传互补异常在散发性和家族性 aHUS 中的相对作用及其对临床表型的影响。
Clin J Am Soc Nephrol. 2010 Oct;5(10):1844-59. doi: 10.2215/CJN.02210310. Epub 2010 Jul 1.
10
Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.识别非典型溶血性尿毒症综合征遗传易感性的流行病学方法。
Ann Hum Genet. 2010 Jan;74(1):17-26. doi: 10.1111/j.1469-1809.2009.00554.x.