Sibson Kristen, Shrontz Abbigail, Jones Jordan, Hooks Olivia, Gerges Maria, Forbes Jessica, Faliv Michelle, Arshad Shaima, Knecht Michelle K, Wyatt Adam T, Casey Robert, Perumareddi Parvathi
Pediatrics, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Population Health and Social Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Cureus. 2025 May 19;17(5):e84399. doi: 10.7759/cureus.84399. eCollection 2025 May.
Vaccine hesitancy is a multi-faceted topic that encompasses many different etiologies and solutions. There remains limited literature regarding effective interventions to target these hesitant cohorts. The objective of our paper was to review existing publications that quantitatively measure if tested interventions resulted in an increase in pediatric vaccine uptake within populations that have been evaluated for vaccine hesitancy. Articles were obtained by performing a database search of PubMed, Embase, and Cochrane databases, as well as through hand-searching. Eligible studies included those published in or after 2013, conducted in the United States on pediatric participants eighteen years or younger, and measured quantitatively the success of an intervention. Eight reviewers screened titles, abstracts, and full texts for inclusion. Rayyan facilitated an organized screening process. Data was hand-extracted and collated into charts to identify trends from the seven final articles. Seven articles describing successful interventions that addressed parental vaccine hesitancy and increased pediatric vaccination rates were analyzed. The most prevalent theme among the interventions was healthcare provider communication (71%), followed by parent education (57%), multi-level interventions (57%), standardization of the vaccination process (43%), and healthcare provider education (23%). There were limitations to this scoping review. While vaccine hesitancy was surveyed pre-intervention in each study, those individuals identified as hesitant were not isolated for the target intervention, apart from one article. Additionally, there were different study outcome measures, which made the statistics not directly comparable. Nonetheless, this scoping review identified recurrent evidence-based themes to increase vaccine uptake in hesitant pediatric populations. These interventions should be implemented in medical education and clinical practices to improve pediatric vaccine coverage.
疫苗犹豫是一个多方面的话题，涵盖了许多不同的病因和解决方案。关于针对这些犹豫群体的有效干预措施的文献仍然有限。我们论文的目的是回顾现有的出版物，这些出版物定量衡量了经过测试的干预措施是否导致在接受过疫苗犹豫评估的人群中儿童疫苗接种率有所提高。通过对PubMed、Embase和Cochrane数据库进行数据库搜索以及手工检索来获取文章。符合条件的研究包括2013年或之后发表的、在美国针对18岁及以下儿童参与者进行的、并定量衡量干预措施成功与否的研究。八位评审员筛选标题、摘要和全文以确定是否纳入。Rayyan促进了有组织的筛选过程。数据通过手工提取并整理成图表，以从七篇最终文章中识别趋势。对七篇描述成功干预措施的文章进行了分析，这些措施解决了家长的疫苗犹豫问题并提高了儿童疫苗接种率。干预措施中最普遍的主题是医疗保健提供者沟通（71%），其次是家长教育（57%）、多层次干预（57%）、疫苗接种过程标准化（43%）和医疗保健提供者教育（23%）。这项范围审查存在局限性。虽然在每项研究中干预前都对疫苗犹豫情况进行了调查，但除了一篇文章外，被确定为犹豫的个体并未被单独作为目标干预对象。此外，研究结果测量方法不同，这使得统计数据无法直接比较。尽管如此，这项范围审查确定了反复出现的基于证据的主题，以提高犹豫儿童群体的疫苗接种率。这些干预措施应在医学教育和临床实践中实施，以提高儿童疫苗接种覆盖率。
