Yuan Yuge, Hao Yujia, Peng Chengcheng, Zhang Duo, Ma Wenzhou, Xiao Pengpeng, Li Nan
Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, China.
College of Veterinary Medicine, Jilin University, Changchun, China.
Front Cell Infect Microbiol. 2025 Jun 4;15:1513392. doi: 10.3389/fcimb.2025.1513392. eCollection 2025.
Getah virus (GETV) is a member of the of the . It is a single-stranded positive-RNA virus that is mainly transmitted by mosquitoes. In recent years, the spread of GETV has become increasingly serious, causing serious losses to the animal economy and posing a potential threat to public health. GETV infected animals extend from traditional domestic animals such as horses and pigs to cattle, foxes and other animals. Especially in China, the virus has been detected in many provinces in recent years. In addition, GETV-specific antibodies were detected in healthy humans. However, the threat posed by GETV in China has not received enough attention. In this study, we downloaded all available GETV genome-wide serials (82 serials in total) from the NCBI as of December 2023. We integrate multiple bioinformatics approaches to understand the characteristics of GETV from the perspectives of epidemiology, virus-host co-evolution, and viral adaptation analysis. The results of this study show that GETV is rapidly expanding its host range and geographical distribution at high evolutionary rates due to the lack of commercially available vaccines. Second, we clearly reveal the cross-species transmission of GETV. Finally, we identified important adaptive and active selection sites. GETV and its media are widely distributed in China, and new host infections continue to appear. Therefore, strengthening surveillance and prevention to avoid serious losses to the pandemic is an important task we face today.
盖塔病毒（GETV）是[此处原文信息不完整]的成员。它是一种单链正RNA病毒，主要通过蚊子传播。近年来，GETV的传播日益严重，给动物经济造成严重损失，并对公共卫生构成潜在威胁。GETV感染的动物范围从马和猪等传统家畜扩展到牛、狐狸等其他动物。特别是在中国，近年来该病毒已在多个省份被检测到。此外，在健康人群中也检测到了GETV特异性抗体。然而，GETV在中国构成的威胁尚未得到足够重视。在本研究中，我们从NCBI下载了截至2023年12月所有可用的GETV全基因组序列（共82个序列）。我们整合多种生物信息学方法，从流行病学、病毒-宿主共同进化和病毒适应性分析等角度了解GETV的特征。本研究结果表明，由于缺乏商业化疫苗，GETV正以高进化速率迅速扩大其宿主范围和地理分布。其次，我们明确揭示了GETV的跨物种传播。最后，我们确定了重要的适应性和正选择位点。GETV及其传播媒介在中国广泛分布，新的宿主感染不断出现。因此，加强监测和预防以避免大流行造成严重损失是我们当今面临的一项重要任务。
