Zhang Xiaoxiao, Li Sijie
Department of Breast Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Front Pharmacol. 2025 Jun 4;16:1587675. doi: 10.3389/fphar.2025.1587675. eCollection 2025.
The high incidence and mortality rates of breast cancer (BC) continue to pose a significant threat to patient survival and life expectancy. An increasing number of recent studies have demonstrated the crucial role of the ubiquitin-proteasome system (UPS) in cancer initiation and progression. Of particular significance is the aberrant expression of the NEDD4 family, which belongs to the HECT-type E3 ubiquitin ligases, in BC progression. This review synthesizes current knowledge about the interactions between the NEDD4 family and various tumor-related signaling pathways and their roles in BC biology, providing a theoretical foundation for exploring novel prognostic markers and treatment strategies.
乳腺癌（BC）的高发病率和死亡率继续对患者的生存和预期寿命构成重大威胁。最近越来越多的研究表明泛素-蛋白酶体系统（UPS）在癌症发生和发展中起关键作用。特别重要的是，属于HECT型E3泛素连接酶的NEDD4家族在BC进展中存在异常表达。本综述综合了有关NEDD4家族与各种肿瘤相关信号通路之间相互作用及其在BC生物学中的作用的现有知识，为探索新的预后标志物和治疗策略提供理论基础。
