通过向输精管注射降低pH值的聚合物对雄性猴子进行避孕

Contraception in male monkeys by intra-vas deferens injection of a pH lowering polymer.

作者信息

Guha S K, Ansari S, Anand S, Farooq A, Misro M M, Sharma D N

出版信息

Contraception. 1985 Jul;32(1):109-18. doi: 10.1016/0010-7824(85)90120-9.

Abstract

A new male method of contraception by injecting a polymer, styrene-maleic anhydride (SMA), into the lumen of the vas deferens has been studied on rhesus monkeys. The polymer has the dual feature that it can occlude the vas deferens lumen and also it can inhibit the fertilising ability of spermatozoa by virtue of the pH lowering effect. Matings with females were carried out when the lumen was completely occluded giving azoospermia as well as with partial block and spermatozoa present in the semen. All matings were infertile. Data up to one year is presented. All indications are that the contraceptive effect will last for a considerably long period.

摘要

一种通过向输精管管腔内注射聚合物苯乙烯-马来酸酐（SMA）实现男性避孕的新方法已在恒河猴身上进行了研究。该聚合物具有双重特性，既能阻塞输精管管腔，又能凭借降低pH值的作用抑制精子的受精能力。当管腔完全阻塞导致无精子症时，以及部分阻塞且精液中存在精子时，均与雌性进行交配。所有交配均未受孕。本文呈现了长达一年的数据。所有迹象表明，避孕效果将持续相当长的一段时间。