Lohiya N K, Alam I, Hussain M, Khan S R, Ansari A S
Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.
Indian J Med Res. 2014 Nov;140 Suppl(Suppl 1):S63-72.
Over the last two decades RISUG has been drawing attention in the field of male contraception. It promises to sterile men for a period of up to 10-15 years. According to recent studies in animal models, it proves to be completely reversible. Practically, there are no better options available that can assure complete sterility and precise reversibility. Regardless of so much of information available, RISUG is still holding up for many reasons, firstly, the available information engender bewilderment such as what is this copolymer, how does it work and is reversal really possible? Secondly, advancement of this outstanding invention is drastically slow and thirdly, effects of long-term contraception with RISUG and reports on evaluation of anomalies (if any) in F 1 , F 2 progenies, are lacking. In this review the lacunae as well as advances in the development of RISUG in the light of published work and available resources are pointed out. Formulation of the RISUG, its mode of action and clinical trials have been addressed with particular emphasis.
在过去二十年里，RISUG（可逆抑制精子发生药物）在男性避孕领域一直备受关注。它有望使男性在长达10至15年的时间内保持不育。根据最近在动物模型上的研究，它被证明是完全可逆的。实际上，没有更好的选择能确保完全不育和精确的可逆性。尽管有这么多可用信息，但由于许多原因，RISUG仍处于停滞状态，首先，现有信息引发了困惑，比如这种共聚物是什么、它如何起作用以及逆转是否真的可行？其次，这项杰出发明的进展极其缓慢，第三，缺乏关于RISUG长期避孕效果以及对F1、F2代子代异常情况（如果有的话）评估的报告。在这篇综述中，根据已发表的工作和可用资源，指出了RISUG发展中的空白以及进展。特别强调了RISUG的配方、作用方式和临床试验。
