Cao Guang-Mei, Yan Si-Shun, Song Lei, Jiang Yuan-Xu, Gao Tian-Yu, Chen Zhen, Zhang Wei, Ye Jian-Heng, Yu Da-Gang
College of Carbon Neutrality Future Technology, Sichuan University, Chengdu 610065, P. R. China.
Leibniz-Institut für Katalyse e.V. (LIKAT), Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
Chem Soc Rev. 2025 Jul 14;54(14):6726-6806. doi: 10.1039/d5cs00181a.
Direct functionalization of unactivated alkenes has emerged as a highly effective strategy for the rapid construction of multi-functional, complex molecular architectures from simple, abundant chemicals. This area of research has garnered increasing attention and continues to be a focus of contemporary chemistry. Recent years have witnessed substantial advancements driven by the discovery of photocatalysis and the expansion of activation strategies, which have led to the discovery of novel transformations and the refinement of established reactions. In this review, we provide a comprehensive overview of the visible-light photocatalytic functionalization of unactivated alkenes, with a particular emphasis on key reactions and mechanistic insights into transformations hydrofunctionalization, difunctionalization and functionalized alkene retention. Furthermore, we discuss the recent progress, ongoing challenges and emerging opportunities in this significant field, highlighting the synthetic utility and potential for future applications.
未活化烯烃的直接官能团化已成为一种高效策略，可从简单、丰富的化学原料快速构建多功能、复杂的分子结构。该研究领域已受到越来越多的关注，并仍然是当代化学的一个重点。近年来，光催化的发现和活化策略的扩展推动了该领域的重大进展，从而促成了新转化反应的发现以及既定反应的优化。在本综述中，我们全面概述了未活化烯烃的可见光光催化官能团化，特别强调了关键反应以及对氢官能团化、双官能团化和官能化烯烃保留等转化反应的机理见解。此外，我们讨论了这一重要领域的最新进展、持续挑战和新出现的机遇，突出了其合成效用和未来应用潜力。
