低温仓鼠通过中枢刺激诱导复温

Induced rewarming by central stimulation in hypothermic hamsters.

作者信息

Resch G E, Simpson C W

出版信息

Cryobiology. 1985 Oct;22(5):490-4. doi: 10.1016/0011-2240(85)90161-0.

Abstract

Helium-cold hypothermic hamsters, colonic temperature (Tc) 7 to 11 degrees C, injected with acetylcholine (ACH) at a preoptic-anterior hypothalamic (AHPOA) site responded with a rise in colonic temperature while remaining in a cold environmental chamber. The He-Cold hamster does not thermoregulate at these body temperatures. In contrast to central ACH-elicited responses, the injection of alpha and beta adrenergic drugs into the systemic circulation of the He-Cold hamster did not elicit a rise in colonic temperature. The data describe a different animal model of rewarming than has previously been described that is under pharmacologic control by the experimenter. The use of exogenous neurotransmitter provides the potential to understand the mechanisms of thermoregulation in deep experimental hypothermia.

摘要

结肠温度（Tc）为7至11摄氏度的氦冷低温仓鼠，在视前区 - 下丘脑前部（AHPOA）部位注射乙酰胆碱（ACH）后，即使仍处于寒冷的环境舱中，结肠温度也会升高。氦冷仓鼠在这些体温下无法进行体温调节。与中枢ACH引发的反应不同，向氦冷仓鼠的体循环中注射α和β肾上腺素能药物不会引起结肠温度升高。这些数据描述了一种与之前所描述的不同的复温动物模型，该模型受实验者的药物控制。使用外源性神经递质为理解深度实验性低温下的体温调节机制提供了可能。