Qingpiao Sun, Yi Zhang
Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301Yanchang Road, Shanghai, 200072, China.
J Cardiovasc Transl Res. 2025 Jun 19. doi: 10.1007/s12265-025-10617-y.
Exosomes are small vesicles secreted by a variety of cells surrounded by a lipid bilayer membrane and containing a variety of biomolecules, of which microRNAs (miRNAs) are the most abundant. Exosomal miRNAs are involved in the development of cardiovascular diseases(CVD), and their unique biological properties make them expected to be effective targets for the treatment of CVD. This article reviews the biological characteristics, expression, and mechanism of action of exosomes and exosomal miRNAs in CVD, as well as their potential as biomarkers in the diagnosis, treatment, and prognostic assessment of CVD, to provide new ideas in the field of CVD medicine.
外泌体是由多种细胞分泌的小囊泡，被脂质双分子层膜包裹，含有多种生物分子，其中微小RNA（miRNA）最为丰富。外泌体miRNA参与心血管疾病（CVD）的发生发展，其独特的生物学特性使其有望成为治疗CVD的有效靶点。本文综述了外泌体及外泌体miRNA在CVD中的生物学特性、表达、作用机制，以及它们作为生物标志物在CVD诊断、治疗和预后评估中的潜力，为心血管疾病医学领域提供新思路。
