Ariestine Dina Aprillia, Kojima Taro, Siregar Fakhriza Hidayati, Ivander Alvin
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Department of Geriatric Medicine, International University of Health and Welfare, Narita, Japan.
Eur Geriatr Med. 2025 Jun 19. doi: 10.1007/s41999-025-01252-6.
This study aims to analyze medication review efficacy toward clinical outcomes in older adults with hip fractures.
A systematic search was conducted using the modified keywords "medication review," "polypharmacy," and "hip fractures" to find relevant studies. Following the PRISMA guidelines, we reviewed published studies from 2014 to 2024. A total of 21 studies have been identified, six of which reported medication reviews for older adults with hip fractures.
The findings highlight the critical need for a multi-faceted strategy to address the challenges of polypharmacy in older adults with hip fractures. A higher number of medications is associated with some adverse outcomes, such as increased hospitalization rates, longer recovery times, and a greater incidence of pressure ulcers. Although minimizing inappropriate medications may show some positive results, focusing solely on medication management is insufficient in this vulnerable population.
Medication reviews have substantially mitigated medication-related issues, including costs, drug efficacy, and patient discomfort. Nevertheless, clinical outcomes have yet to exhibit significant improvement, which presents an opportunity for further research to explore the potential benefits of medication reviews in enhancing the care of patients with hip fractures. A holistic approach, which consists of medication review, patient education, and tailored rehabilitation programs, may be essential to improve recovery, decrease hospitalization rates, and prevent adverse events.
本研究旨在分析药物重整对髋部骨折老年患者临床结局的疗效。
使用修改后的关键词“药物重整”“多重用药”和“髋部骨折”进行系统检索，以查找相关研究。按照PRISMA指南，我们检索了2014年至2024年发表的研究。共识别出21项研究，其中6项报告了针对髋部骨折老年患者的药物重整情况。
研究结果凸显了采取多方面策略应对髋部骨折老年患者多重用药挑战的迫切需求。用药数量较多与一些不良结局相关，如住院率增加、恢复时间延长以及压疮发生率更高。尽管尽量减少不适当用药可能会显示出一些积极效果，但仅专注于药物管理对这一脆弱人群而言是不够的。
药物重整在很大程度上缓解了与药物相关的问题，包括成本、药物疗效和患者不适。然而，临床结局尚未有显著改善，这为进一步研究探索药物重整在改善髋部骨折患者护理方面的潜在益处提供了契机。一种由药物重整、患者教育和量身定制的康复计划组成的整体方法，可能对于改善康复、降低住院率和预防不良事件至关重要。
