Roberts Trevor D, Arnett Jocelyn E, Ortega Dolores G, Pioske Justin S, Daugherty F Joseph, Tempesta Michael S, Dash Alekha K, Schmidt Richard J, Housh Terry J
Department of Nutrition and Health Sciences, Exercise Physiology Laboratory, University of Nebraska-Lincoln, Lincoln, NE, USA.
Phenolics LLC, Omaha, NE, USA.
J Diet Suppl. 2025;22(4):584-612. doi: 10.1080/19390211.2025.2518408. Epub 2025 Jun 19.
Although creatine monohydrate (CM), leucine, and polyphenols have been independently researched, there is a lack of research on the effects of a supplementation blend containing trisodium citrate, CM, leucine, and blueberry extract (TCLB) on muscle strength, endurance, and size. This study compared the effects of 8 wk of supplementation with TCLB versus CM and placebo (PLA) combined with resistance training on leg extension strength, endurance, and muscle size. Twenty-eight recreationally active men ingested either TCLB ( = 10), CM ( = 10), or PLA ( = 8) during 8 wk of resistance training. Leg extension 1-repetition maximum (1RM), leg extension repetitions-to-failure at ∼80% of pre-training 1RM, individual quadriceps cross-sectional area (CSA) values, and the sum of the CSA values (CSA) were assessed at pre-training and post-training. Separate one-way ANCOVAs covaried for pre-training values were used to analyze differences in adjusted post-training means. Separate Chi-squared tests were used to analyze differences between groups in the proportion of subjects that exceeded the minimal important difference (MID). There were no group differences ( > 0.05) for leg extension 1RM, leg extension repetitions-to-failure, rectus femoris CSA, vastus lateralis CSA, or vastus medialis CSA. The TCLB group demonstrated greater ( ≤ 0.05) adjusted post-training means and proportions of subjects who exceeded the MID for the CSA and vastus intermedius CSA than the PLA group, but the TCLB group did not differ ( > 0.05) from the CM group for those variables. The CM group ( ≤ 0.05) exhibited a greater proportion of subjects who exceeded the MID for the CSA than the PLA group. These findings indicated that 8 wk of supplementation with TCLB and CM combined with resistance training increased the overall quadriceps muscle size greater than the PLA, but TCLB did not differ from CM. Furthermore, the groups did not differ in the training-induced increases in leg extension strength and endurance.
尽管一水肌酸（CM）、亮氨酸和多酚已分别得到研究，但对于含有柠檬酸三钠、CM、亮氨酸和蓝莓提取物（TCLB）的补充剂混合物对肌肉力量、耐力和尺寸的影响却缺乏研究。本研究比较了8周补充TCLB与CM及安慰剂（PLA）并结合抗阻训练对伸腿力量、耐力和肌肉尺寸的影响。28名有休闲运动习惯的男性在8周抗阻训练期间分别摄入TCLB（n = 10）、CM（n = 10）或PLA（n = 8）。在训练前和训练后评估伸腿1次重复最大值（1RM）、以训练前1RM的约80%进行伸腿至力竭的重复次数、个体股四头肌横截面积（CSA）值以及CSA值总和（CSA）。使用针对训练前值进行协变量调整的单因素协方差分析来分析调整后训练后均值的差异。使用独立的卡方检验来分析各组中超过最小重要差异（MID）的受试者比例的差异。伸腿1RM、伸腿至力竭的重复次数、股直肌CSA、股外侧肌CSA或股内侧肌CSA在各组之间无差异（P>0.05）。与PLA组相比，TCLB组在调整后训练后均值以及超过CSA和股中间肌CSA的MID的受试者比例方面表现更优（P≤0.05），但在这些变量上TCLB组与CM组无差异（P>0.05）。CM组超过CSA的MID的受试者比例高于PLA组（P≤0.05）。这些结果表明，8周补充TCLB和CM并结合抗阻训练比PLA更能增加股四头肌的整体肌肉尺寸，但TCLB与CM无差异。此外，各组在训练诱导的伸腿力量和耐力增加方面无差异。
