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使用Target Tetra线圈治疗小型和超小型破裂颅内动脉瘤的早期经验。

Early experience with Target Tetra coils for treatment of small and very small ruptured intracranial aneurysms.

作者信息

Mehta Amol, Finesilver Joshua, Goldman Daryl, Shigematsu Tomoyoshi, Kellner Christopher P, Majidi Shahram, De Leacy Reade, Fifi Johanna, Caton Michael Travis

机构信息

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

Interv Neuroradiol. 2025 Jun 20:15910199251351735. doi: 10.1177/15910199251351735.

Abstract

BackgroundEndovascular treatment of small (< 5 mm) and very small (≤ 3 mm) ruptured intracranial aneurysms remains technically challenging, historically carrying elevated procedural risks. Advances in coil technology, such as the Target Tetra Detachable Coil (TTDC), aim to improve embolization safety and efficacy. However, limited data exist on outcomes using TTDC coils specifically for ruptured aneurysms.ObjectiveTo evaluate the safety, angiographic efficacy, and clinical outcomes of TTDC for small and very small ruptured intracranial aneurysms.MethodsWe retrospectively analyzed 36 patients with ruptured intracranial aneurysms ≤5 mm treated using TTDC between 2023 and 2025 at a single center. Aneurysms were classified as small ( = 28) or very small ( = 8). Patient demographics, aneurysm characteristics, procedural details, angiographic outcomes, clinical outcomes, and complications were analyzed.ResultsMedian patient age was 57 years (IQR 43-73); 33.3% were male. The mean aneurysm dome height was 2.6 ± 0.9 mm, the mean neck diameter was 2.4 ± 0.7 mm, and the median dome-to-neck ratio was 1.0. Immediate complete occlusion (Raymond-Roy Class I) was achieved in 42.7% of aneurysms, and residual neck filling (Raymond-Roy Class II) in 25.0%. Follow-up imaging (mean 4.9 months) showed complete occlusion in 37.5% of aneurysms. Recanalization occurred in 29.2% of patients with repeat imaging and 6 (25%) requiring retreatment. Favorable clinical outcomes (mRS 0-2) occurred in 75.0%. Procedural complications occurred in 13.9% (five cases), including two intraprocedural perforations. No rebleeding occurred.ConclusionEarly experience with TTDC demonstrates safe, effective embolization for ruptured small and very small intracranial aneurysms, supporting the broader use of modern coils in these challenging lesions.

摘要

背景

小型(<5 mm)和超小型(≤3 mm)破裂颅内动脉瘤的血管内治疗在技术上仍然具有挑战性,历来手术风险较高。线圈技术的进步,如Target Tetra可脱卸线圈(TTDC),旨在提高栓塞的安全性和有效性。然而,专门针对破裂动脉瘤使用TTDC线圈的疗效数据有限。

目的

评估TTDC治疗小型和超小型破裂颅内动脉瘤的安全性、血管造影疗效及临床结果。

方法

我们回顾性分析了2023年至2025年在单一中心使用TTDC治疗的36例颅内动脉瘤破裂且直径≤5 mm的患者。动脉瘤分为小型(n = 28)或超小型(n = 8)。分析患者人口统计学、动脉瘤特征、手术细节、血管造影结果、临床结果及并发症。

结果

患者中位年龄为57岁(四分位间距43 - 73岁);33.3%为男性。动脉瘤平均瘤顶高度为2.6±0.9 mm,平均颈部直径为2.4±0.7 mm,瘤顶与颈部比例中位数为1.0。42.7%的动脉瘤实现即刻完全栓塞(Raymond - Roy I级),25.0%存在残余颈部显影(Raymond - Roy II级)。随访影像(平均4.9个月)显示37.5%的动脉瘤完全栓塞。29.2%接受重复影像检查的患者发生再通,6例(25%)需要再次治疗。75.0%患者获得良好临床结局(改良Rankin量表0 - 2分)。手术并发症发生率为13.9%(5例),包括2例术中穿孔。无再出血发生。

结论

TTDC的早期经验表明,其对破裂的小型和超小型颅内动脉瘤进行栓塞安全有效,支持在这些具有挑战性的病变中更广泛地使用现代线圈。

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本文引用的文献

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Endovascular Treatment of Very Small Intracranial Aneurysms: Meta-Analysis.微小颅内动脉瘤的血管内治疗:荟萃分析
AJNR Am J Neuroradiol. 2016 May;37(5):862-7. doi: 10.3174/ajnr.A4651. Epub 2015 Dec 31.
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The Barrow Ruptured Aneurysm Trial.巴罗破裂动脉瘤试验。
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