Zou Peng, Xiao Fu, Wei Yusong, Chen Chengru, Wu Xiaobin
Department of Gastrointestinal Surgery, The Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen 518033, Guangdong Province, China.
Br J Nutr. 2025 Jun 20:1-37. doi: 10.1017/S0007114525103693.
The composite dietary antioxidant index (CDAI) has been identified as a critical factor in the pathogenesis of certain inflammatory diseases. The study aimed to investigate the relationship between CDAI and () infection using cross-sectional design. In this study, participants from the 1999-2000 National Health and Nutrition Examination Survey (NHANES) were analyzed using logistic and Cox regression analyses to assess the associations between infection and CDAI, encompassing vitamin A, vitamin C, vitamin E, carotene, zinc, selenium, and copper. The results demonstrated a negative correlation between CDAI scores and infection, revealing a non-linear relationship between the odds of infection and CDAI as a continuous variable. Subsequently, a two-sample Mendelian randomization (MR) study was conducted utilizing genome-wide association study (GWAS) summary statistics to explore the causal relationship between antioxidant levels and infection. We found that the intake of copper was a protective factor in the occurrence of infection but did not support a causal association between circulating copper levels and infection. The prevalence of infection was found to be elevated among individuals of older age, lower education levels, limited socioeconomic status, smokers, diabetes, and those with hypertension. The study suggests that higher CDAI is linked to a decreased odds of infection, and further prospective studies are needed to confirm the association. Our findings may have significant implications for the prevention and management of -related diseases.
复合膳食抗氧化指数（CDAI）已被确定为某些炎症性疾病发病机制中的一个关键因素。该研究旨在采用横断面设计调查CDAI与（）感染之间的关系。在本研究中，对1999 - 2000年国家健康和营养检查调查（NHANES）的参与者进行了逻辑回归和Cox回归分析，以评估感染与CDAI之间的关联，CDAI涵盖维生素A、维生素C、维生素E、胡萝卜素、锌、硒和铜。结果表明CDAI评分与感染之间呈负相关，揭示了作为连续变量的感染几率与CDAI之间的非线性关系。随后，利用全基因组关联研究（GWAS）汇总统计数据进行了一项两样本孟德尔随机化（MR）研究，以探讨抗氧化剂水平与感染之间的因果关系。我们发现铜的摄入量是感染发生的一个保护因素，但不支持循环铜水平与感染之间存在因果关联。研究发现，在年龄较大、教育水平较低、社会经济地位有限、吸烟者、糖尿病患者以及高血压患者中，感染的患病率有所升高。该研究表明，较高的CDAI与感染几率降低有关，需要进一步的前瞻性研究来证实这种关联。我们的研究结果可能对相关疾病的预防和管理具有重要意义。
