Fonseca Carlos D F, Zendulka Ondřej, Juřica Jan
Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechia.
Masaryk Memorial Cancer Institute, Brno, Czechia.
Front Pharmacol. 2025 Jun 5;16:1599012. doi: 10.3389/fphar.2025.1599012. eCollection 2025.
The use of cannabinoids has a history spanning thousands of years, and their pharmacological and toxicological properties, particularly those of THC and CBD, are well-documented. However, their potential to induce drug-drug interactions remains underexplored. This review aims to provide a comprehensive perspective by contextualizing the historical and pharmacological significance of cannabinoids while focusing on their capacity to modulate the metabolic activity of cytochrome P450 isoforms relevant to drug metabolism. Additionally, we look at the impact of cannabinoids in neuronal circuits impacting the hypothalamic-pituitary hormonal axis, such as the and and their possible consequences on the cytochrome P450 system. Recognising potential interactions between cannabinoids and other drugs could enhance understanding of their pharmacological effects, improve the efficacy and safety profiles of cannabinoid-based therapies, and encourage further exploration into this under-researched area of psychopharmacology, with implications for both preclinical research and clinical practice.
大麻素的使用已有数千年历史，其药理和毒理学特性，尤其是四氢大麻酚（THC）和大麻二酚（CBD）的特性，已有充分记录。然而，它们诱导药物相互作用的潜力仍未得到充分探索。本综述旨在通过阐述大麻素的历史和药理学意义，同时关注其调节与药物代谢相关的细胞色素P450同工酶代谢活性的能力，提供一个全面的视角。此外，我们研究大麻素在影响下丘脑 - 垂体激素轴的神经回路中的作用，如[此处原文缺失相关内容]及其对细胞色素P450系统可能产生的后果。认识到大麻素与其他药物之间的潜在相互作用，有助于加深对其药理作用的理解，改善基于大麻素疗法的疗效和安全性，并鼓励进一步探索这一精神药理学研究不足的领域，这对临床前研究和临床实践都具有重要意义。
