Wang Zexun, Sun Wangqing, Zhang Kai, Ke Xianjin, Wang Zhongqun
Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China; Institue of Cardiovascular Diseases, Jiangsu University, Zhenjiang 212001, China.
Department of Radiology, Yixing Tumor Hospital, Yixing 214200, China.
Cell Signal. 2025 Mar;127:111580. doi: 10.1016/j.cellsig.2024.111580. Epub 2024 Dec 26.
Atherosclerotic cardiovascular and cerebrovascular diseases are the number one killer of human health. In view of the important role of mitochondria in the formation and evolution of atherosclerosis, our manuscript aims to comprehensively elaborate the relationship between mitochondria and the formation and evolution of atherosclerosis from the aspects of mitochondrial dynamics, mitochondria-organelle interaction (communication), mitochondria and cell death, mitochondria and vascular smooth muscle cell phenotypic switch, etc., which is combined with genome, transcriptome and proteome, in order to provide new ideas for the pathogenesis of atherosclerosis and the diagnosis and treatment of related diseases.
动脉粥样硬化性心脑血管疾病是人类健康的头号杀手。鉴于线粒体在动脉粥样硬化形成和演变中的重要作用，我们的稿件旨在从线粒体动力学、线粒体-细胞器相互作用（通讯）、线粒体与细胞死亡、线粒体与血管平滑肌细胞表型转换等方面，结合基因组、转录组和蛋白质组，全面阐述线粒体与动脉粥样硬化形成和演变之间的关系，为动脉粥样硬化的发病机制及相关疾病的诊断和治疗提供新思路。
