Ganesan Ovya, Kiwanuka Harriet, Hamaguchi Ryoko, Orgill Dennis P
Geisel School of Medicine at Dartmouth, Hanover, NH, United States.
Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, MA, United States.
Front Surg. 2025 Jun 5;12:1504563. doi: 10.3389/fsurg.2025.1504563. eCollection 2025.
Regenerative medicine and tissue engineering explore the potential to enhance human healing, which is often limited by wound contraction, scarring, loss of function, and decreased quality of life. Biomaterials like synthetic scaffolds and implantable devices have been developed to circumvent the body's limited natural ability to heal, however, they may introduce their own complications such as toxic side effects. Advances in cell-based therapies, especially those involving embryonic stem cells (ESCs) and human-induced pluripotent stem cells (hiPSCs), offer an enhanced ability to regenerate, circumventing limitations of biomaterials and the body's limited ability to heal. There have been many recent advances in cell-therapies, both scaffold-based and scaffold-free products. Additionally, non-cell-based therapies are gaining traction in wound healing. These products, utilizing their ability to affect the principles of wound healing, have applications in anti-aging. Despite these advances, significant challenges remain. These technologies remain costly, may compromise ethical tenets, and may introduce safety risks. Future work should address these challenges.
再生医学和组织工程探索增强人类愈合能力的潜力，而人类愈合能力常常受到伤口收缩、瘢痕形成、功能丧失和生活质量下降的限制。诸如合成支架和可植入装置等生物材料已被开发出来，以规避人体有限的自然愈合能力，然而，它们可能会引发自身的并发症，如毒副作用。基于细胞的疗法取得了进展，尤其是那些涉及胚胎干细胞（ESC）和人类诱导多能干细胞（hiPSC）的疗法，提供了更强的再生能力，规避了生物材料的局限性和人体有限的愈合能力。最近在基于支架和无支架产品的细胞疗法方面取得了许多进展。此外，非细胞疗法在伤口愈合方面越来越受到关注。这些产品利用其影响伤口愈合原理的能力，在抗衰老方面有应用。尽管取得了这些进展，但仍存在重大挑战。这些技术成本仍然很高，可能会违背伦理原则，并可能带来安全风险。未来的工作应应对这些挑战。
