Domaszewska-Szostek Anna, Krzyżanowska Marta, Polak Agnieszka, Puzianowska-Kuźnicka Monika
Department of Human Epigenetics, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland.
Int J Mol Sci. 2025 Mar 6;26(5):2354. doi: 10.3390/ijms26052354.
In recent years, there has been a dynamic development in therapies utilizing extracellular vesicles (EVs) including exosomes. Therefore, we have conducted an analysis of the scientific literature to verify the current state of knowledge about these therapies. A total of 12 clinical studies were analyzed, covering the use of EVs in treating skin aging, acne scars, alopecia, and wound healing. The results indicate that EVs and exosomes hold potential in regenerative skin therapies, offering innovative and non-invasive therapeutic approaches. At the same time, significant challenges related to the standardization of their production and the lack of large-scale randomized studies were identified. Thus, we also evaluated the investigated clinical trials in regard to the MISEV (Minimal Information for Studies of Extracellular Vesicles) criteria. This review provides a comprehensive overview of the contemporary applications of EVs in skin therapy and regenerative medicine, highlighting directions for further research.
近年来，包括外泌体在内的利用细胞外囊泡（EVs）的疗法有了蓬勃发展。因此，我们对科学文献进行了分析，以核实有关这些疗法的当前知识状况。共分析了12项临床研究，涵盖了EVs在治疗皮肤老化、痤疮疤痕、脱发和伤口愈合方面的应用。结果表明，EVs和外泌体在再生皮肤疗法中具有潜力，提供了创新的非侵入性治疗方法。同时，还发现了与它们生产的标准化相关的重大挑战以及缺乏大规模随机研究的问题。因此，我们还根据细胞外囊泡研究的最低信息（MISEV）标准对所调查的临床试验进行了评估。本综述全面概述了EVs在皮肤治疗和再生医学中的当代应用，突出了进一步研究的方向。
