Muto T, Kamiya J, Sawada T, Konishi F, Sugihara K, Kubota Y, Adachi M, Agawa S, Saito Y, Morioka Y
Dis Colon Rectum. 1985 Nov;28(11):847-51. doi: 10.1007/BF02555490.
Thirty-three small "flat adenomas," not more than 1 cm in diameter, were collected from surgically and colonoscopically removed specimens, and their colonoscopic and histologic characteristics were described. There were 14 adenomas with mild atypia, five with moderate atypia, 14 with severe atypia (or focal carcinoma limited to the mucosa). The grade of atypia seems to increase with the size of lesions, and these lesions were assumed to play an important role in the adenoma-carcinoma sequence. The importance of recognizing the presence of these small "flat adenomas" in everyday practice is stressed.
从手术切除标本和结肠镜切除标本中收集了33个直径不超过1厘米的小“扁平腺瘤”，并描述了它们的结肠镜和组织学特征。其中有14个腺瘤具有轻度异型性，5个具有中度异型性，14个具有重度异型性（或局限于黏膜的局灶性癌）。异型性程度似乎随病变大小增加，并且这些病变被认为在腺瘤-癌序列中起重要作用。强调了在日常实践中识别这些小“扁平腺瘤”存在的重要性。
