乙醇与铟-111标记膜的相互作用：用扰动角关联-和峰比法进行评估。

Interaction of ethanol with 111In-labelled membranes: evaluation by the perturbed angular correlation-sum peak ratio method.

作者信息

Jay M, Woodward M A

出版信息

Drug Alcohol Depend. 1985 Aug;15(4):341-6. doi: 10.1016/0376-8716(85)90011-0.

Abstract

The interaction of ethanol with erythrocyte ghosts and vesicles composed of brain lipid extracts labelled with indium-111 was studied using the sum peak ratio method of perturbed angular correlation measurements. Membranes from animals that were fed diets containing ethanol for 10 days demonstrated resistance to the decrease in sum peak ratio values observed in control animals. Thus, repeated administration of ethanol induces changes in the properties of biological membranes, possibly by altering phospholipid composition, which is reflected in the anisotropy of membrane-associated 111In-labelled nuclei as measured by sum peak ratios.

摘要

使用扰动角关联测量的和峰比方法，研究了乙醇与用铟 - 111标记的脑脂质提取物组成的红细胞血影和囊泡之间的相互作用。给动物喂食含乙醇的饲料10天，其细胞膜对对照动物中观察到的和峰比值降低具有抗性。因此，反复给予乙醇可能通过改变磷脂组成诱导生物膜性质的变化，这通过和峰比测量反映在膜相关的111In标记核的各向异性上。