Gao Ming, Pan Wei, Ma Tianqi, Pen Qunyong, Cao Rong, Zhao Chenxuan, Yi Jun
Department of Cardiology, Center of Coronary Circulation, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, China.
Department of Geriatric Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, 410008, China.
J Cardiovasc Transl Res. 2025 Jun 20. doi: 10.1007/s12265-025-10644-9.
Systolic blood pressure variability (SBPV) and arterial stiffness index (ASI) are risk factors for cardiovascular diseases (CVD), but their independent and combined effects remain unclear. This study investigated their associations using data from 28,792 UK Biobank participants without CVD at baseline. SBPV and ASI were categorized into quartiles, and Cox regression was used to assess their effects on CVD risk. Over an average follow-up of 12.29 years, 3,967 CVD events occurred. Higher SBPV and ASI were independently associated with increased CVD risk (SBPV Q4: HR 1.25 [1.14-1.38]; ASI Q4: HR 1.24 [1.12-1.36]). A multiplicative interaction was observed (p = 0.019), and their combined effect further elevated risk (SBPV Q4 + ASI Q4: HR 1.63 [1.32-2.02]). These findings suggest SBPV and ASI independently and jointly contribute to CVD risk, highlighting the need for targeted interventions.
收缩压变异性（SBPV）和动脉僵硬度指数（ASI）是心血管疾病（CVD）的危险因素，但其独立作用和联合作用仍不明确。本研究利用英国生物银行中28792名基线时无CVD的参与者的数据，调查了它们之间的关联。将SBPV和ASI分为四分位数，并使用Cox回归评估它们对CVD风险的影响。在平均12.29年的随访期间，发生了3967例CVD事件。较高的SBPV和ASI与CVD风险增加独立相关（SBPV Q4：HR 1.25 [1.14 - 1.38]；ASI Q4：HR 1.24 [1.12 - 1.36]）。观察到存在相乘交互作用（p = 0.019），它们的联合作用进一步增加了风险（SBPV Q4 + ASI Q4：HR 1.63 [1.32 - 2.02]）。这些发现表明SBPV和ASI独立且共同促成CVD风险，凸显了针对性干预的必要性。
