Liang Jianyi, Davoodi Hossein, Chau-Nguyen Khai, Badilita Vlad, Korvink Jan G
Karlsruhe Institute of Technology (KIT), Institute of Microstructure Technology (IMT), Eggenstein-Leopoldshafen, Karlsruhe, 76344, Germany.
Littelfuse Inc., Lampertheim, 68623, Germany.
Sci Rep. 2025 Jun 20;15(1):20162. doi: 10.1038/s41598-025-05476-1.
In the field of nuclear magnetic resonance (NMR), planar spiral detector coils have been exploited for their ease of fabrication with a high tolerance for accommodating flat samples and for the ability to be integrated with microfluidic systems. Additionally, recent studies demonstrated the feasibility of designing such micro planar spirals for broadband operation. Here we explore a novel embodiment of the planar spiral with a third contact added at an intermediary position of the spiral track, which thereby acts as a double-channel NMR detector. The spiral geometry was optimized through simulation so that the inner loop and the full loop correspond to two frequency bands of interest. With the combined microfluidic and NMR devices fabricated for the first time in low-temperature co-fired ceramic (LTCC) technology, we demonstrate untuned broadband operation by presenting 1D NMR spectra of 4 isotopes from 125 MHz to 500 MHz, as well as 2D [Formula: see text] HSQC measurements. The design is easy to use and shows high robustness, demonstrating potential for NMR studies of flow systems with multiple nuclei.
在核磁共振(NMR)领域,平面螺旋探测器线圈因其易于制造、对容纳扁平样品具有高耐受性以及能够与微流体系统集成而得到应用。此外,最近的研究证明了设计这种用于宽带操作的微平面螺旋的可行性。在这里,我们探索了一种平面螺旋的新颖实施方案,即在螺旋轨道的中间位置添加第三个触点,从而使其成为双通道NMR探测器。通过模拟对螺旋几何结构进行了优化,以使内环和全环对应于两个感兴趣的频带。利用首次采用低温共烧陶瓷(LTCC)技术制造的微流体和NMR组合装置,我们通过展示125 MHz至500 MHz范围内4种同位素的一维NMR谱以及二维[公式:见正文] HSQC测量结果,证明了无需调谐的宽带操作。该设计易于使用且显示出高稳健性,展示了用于多原子核流动系统NMR研究的潜力。