This study aims to investigate the prevalence and trends of USD in Kazakhstan using retrospective data from the Unified National Electronic Health System (UNEHS), spanning from 2014 to 2021. Urinary stone disease (USD), a prevalent urological condition globally, is characterized by the formation of stones in any part of the urinary tract, including the kidneys, ureters, bladder, or urethra. A total of 162,538 hospitalization records from 132,915 patients diagnosed with urolithiasis were analyzed. The study reveals an overall hospitalization prevalence of 1.31 per 1,000 individuals, with the highest rates observed in the southern regions, including Turkestan and Almaty, which align with the geographical characteristics of the "stone belt." Demographic data show a predominance of hospitalizations among individuals aged 50 and above, with a near-equal gender distribution, reflecting a global trend of increasing USD prevalence in women. The urban-rural disparity in hospitalization rates highlights a higher burden in urban areas, potentially due to lifestyle and healthcare access factors. Surgical interventions, particularly ureteral and kidney surgeries, were most frequently performed in urban hospitals. Despite significant healthcare improvements, the study underscores the need for more detailed epidemiological data on USD in Kazakhstan, emphasizing regional, environmental, and socioeconomic factors. The findings provide critical insights for public health strategies and resource allocation aimed at addressing the growing burden of USD in Kazakhstan.