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自身免疫性疾病与妊娠——生出患病孩子的风险更高吗?

Autoimmune Diseases and Pregnancy - Is There a Greater Risk of Giving Birth to a Sick Child?

作者信息

Pszczołowska Magdalena, Walczak Kamil, Kołodziejczyk Weronika, Mroziak Magdalena, Kozłowski Gracjan, Leszek Jerzy

机构信息

Clinic of Psychiatry, Department of Psychiatry, Medical Department, Wrocław Medical University, Wrocław, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 2025 Jun 14;73(1). doi: 10.2478/aite-2025-0017. eCollection 2025 Jan 1.

DOI:10.2478/aite-2025-0017
PMID:40544482
Abstract

This study aims to describe the impact of some of the most common autoimmune diseases, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), myasthenia gravis (MG), chronic inflammatory bowel disease (IBD), type 1 diabetes (T1D), autoimmune thyroid disease, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, vasculitis, and antiphospholipid syndrome (APS), on pregnancy in women. This review investigates the risk to the offspring of the women; that is, whether the mother's disease may affect fertility or disturb fetal development.

摘要

本研究旨在描述一些最常见的自身免疫性疾病,如多发性硬化症(MS)、视神经脊髓炎谱系障碍(NMOSD)、重症肌无力(MG)、慢性炎症性肠病(IBD)、1型糖尿病(T1D)、自身免疫性甲状腺疾病、类风湿性关节炎(RA)、系统性红斑狼疮(SLE)、银屑病、血管炎和抗磷脂综合征(APS)对女性妊娠的影响。本综述调查了这些女性后代面临的风险;也就是说,母亲的疾病是否会影响生育能力或干扰胎儿发育。

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Arch Immunol Ther Exp (Warsz). 2025 Jun 14;73(1). doi: 10.2478/aite-2025-0017. eCollection 2025 Jan 1.
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本文引用的文献

1
Behçet's Disease and Pregnancy: A Retrospective Case-control Study.白塞病与妊娠:一项回顾性病例对照研究。
Yale J Biol Med. 2021 Dec 29;94(4):585-592. eCollection 2021 Dec.
2
Hypothyroidism: Diagnosis and Treatment.甲状腺功能减退症:诊断与治疗。
Am Fam Physician. 2021 May 15;103(10):605-613.
3
Psoriasis and psoriatic arthritis overview.银屑病和银屑病关节炎概述。
Am J Manag Care. 2016 Jun;22(8 Suppl):s216-24.
4
IBD and Pregnancy.炎症性肠病与妊娠
MedGenMed. 2004 Oct 8;6(4):14.
5
Effect of pregnancy on the clinical course of a cohort of women with inflammatory bowel disease.妊娠对一组炎症性肠病女性临床病程的影响。
Ital J Gastroenterol. 1996 May;28(4):199-204.