Liu Wenjun, Li Shanshan, Yu Yue, Cheng Lele, Meng Zixuan, Xue Yaxuan, Liu Renjie, Liu Hui, Yang Jian, Wu Yue, Jian Zhijie
Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Obes Facts. 2025 Jun 21:1-15. doi: 10.1159/000546406.
Weight gain is associated with cardiac abnormalities, but the differences in cardiac remodeling between overweight and obesity (O&O) remain unclear. This study explored the structural and functional cardiac changes associated with O&O using noninvasive imaging.
A retrospective study included participants from August 2021 to July 2023. Clinical data, laboratory results, and echocardiography reports were collected, and cardiac magnetic resonance imaging was post-processed. Cardiac structural and functional parameters were compared among healthy weight, overweight, and obesity groups, and their relationships with body mass index (BMI) were analyzed.
A total of 275 participants were included. Significant differences in left ventricular end-diastolic/systolic diameters, left atrial diameter, left ventricular ejection fraction, and stroke volume index were observed between O&O and healthy weight groups (p < 0.05). However, no significant differences were found between the O&O groups in terms of left ventricular septum thickness, left ventricular posterior wall thickness, cardiac index, or end-systolic volume index (p > 0.05). Multivariable regression showed a positive correlation between BMI and cardiac structural/functional indicators (p < 0.05), with greater changes in obesity. Loess spline analysis revealed that cardiac remodeling was more pronounced during the overweight stage.
Both O&O are associated with larger cardiac dimensions, increased myocardial mass, and impaired function. Cardiac remodeling accelerates during the overweight stage, emphasizing the need for early detection and intervention in overweight individuals to mitigate future health risks.
体重增加与心脏异常有关，但超重和肥胖（O&O）之间心脏重塑的差异仍不清楚。本研究使用无创成像技术探索了与O&O相关的心脏结构和功能变化。
一项回顾性研究纳入了2021年8月至2023年7月的参与者。收集了临床数据、实验室结果和超声心动图报告，并对心脏磁共振成像进行了后处理。比较了健康体重、超重和肥胖组的心脏结构和功能参数，并分析了它们与体重指数（BMI）的关系。
共纳入275名参与者。在O&O组和健康体重组之间，观察到左心室舒张末期/收缩末期直径、左心房直径、左心室射血分数和每搏输出量指数存在显著差异（p<0.05）。然而，在O&O组之间，左心室间隔厚度、左心室后壁厚度、心脏指数或收缩末期容积指数方面未发现显著差异（p>0.05）。多变量回归显示BMI与心脏结构/功能指标之间存在正相关（p<0.05），肥胖时变化更大。局部加权散点平滑分析显示，超重阶段心脏重塑更为明显。
O&O均与心脏尺寸增大、心肌质量增加和功能受损有关。超重阶段心脏重塑加速，强调需要对超重个体进行早期检测和干预，以降低未来的健康风险。
