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[心脏瓣膜手术中经冠状静脉窦逆行灌注心脏停搏液的心肌保护。即刻结果与技术考量]

[Myocardial protection in valvular surgery by retroperfusion of the coronary sinus with cardioplegic solution in valve surgery. Immediate results and technical considerations].

作者信息

Fundarò P, Salati M, Botta M, Velardi A R, Castelli P, Ottomano C, Santoli C

出版信息

G Ital Cardiol. 1985 May;15(5):507-13.

PMID:4054488
Abstract

Retrograde coronary sinus perfusion as a means of delivering cardioplegia was evaluated in 20 patients undergoing cardiac valve surgery. Other 10 patients, undergoing similar operation with antegrade coronary cardioplegic perfusion served as a control. Results showed no significant differences between the two groups of patients in terms of: myocardial cooling; pre-ischemic and post-perfusion myocardial lactate extraction; post-operative clinical findings (myocardial infarction occurrence, need for inotropic support, mortality). We conclude that retroperfusion through the coronary sinus is a safe and effective alternative of cardioplegic delivery. Since it simplifies the operative procedure (it allows the cardioplegia delivery at any desired time of the operation, without discontinuing the procedure), we recommended its use during valvular cardiac operations, especially on aortic valve replacement.

摘要

对20例接受心脏瓣膜手术的患者评估了逆行冠状静脉窦灌注作为输送心脏停搏液的一种方法。另外10例接受类似手术并采用顺行冠状动脉心脏停搏液灌注的患者作为对照。结果显示,两组患者在以下方面无显著差异:心肌降温;缺血前和灌注后心肌乳酸摄取;术后临床结果(心肌梗死发生率、是否需要使用正性肌力支持、死亡率)。我们得出结论,通过冠状静脉窦逆行灌注是一种安全有效的输送心脏停搏液的替代方法。由于它简化了手术操作(它允许在手术的任何需要时间输送心脏停搏液,而无需中断手术过程),我们建议在心脏瓣膜手术中使用,尤其是在主动脉瓣置换术中。

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