Aydemir Selim, Aydın Sidar Şiyar, Altınkaya Onur, Özmen Murat, Özkoç Mustafa, Aksakal Emrah
Department of Cardiology, University of Health Sciences, Erzurum, Turkey.
Biomark Med. 2025 Jul;19(14):589-596. doi: 10.1080/17520363.2025.2523238. Epub 2025 Jun 22.
Coronary artery ectasia (CAE) is localized or generalized dilatation of the coronary artery lumen. CAE is difficult to diagnose, treat, and manage and is associated with the risk of adverse cardiovascular events. In our study, we aimed to evaluate and compare these predictive parameters of CAE.
MATERIALS & METHODS: We conducted a study that involved analyzing patients who had underwent angiography for acute coronary syndrome. The patients were categorized into two groups based on the presence or absence of CAE. The Cox regression analysis considered significant predictors for CAE while assessing independent variables. ROC Curve analysis was used to evaluate the predictive capability of these variables for CAE, and area under the curve (AUC) values were compared.
2279 patients included in the study were followed for an average of 498 days. Coronary ectasia was present in 5.35% of the patients. LDL/HDL ratio and lymphocyte count independently predicted CAE.
In our study, low density lipoprotein/high density lipoprotein (LDL/HDL) ratio and lymphopenia were observed to independently predict CAE. LDL/HDL ratio obtained from standard blood tests can be used as a cost-effective and simple method to predict CAE, making a significant contribution to treatment planning, prognosis and patient follow-up.
冠状动脉扩张（CAE）是冠状动脉管腔的局限性或全身性扩张。CAE难以诊断、治疗和管理，且与不良心血管事件风险相关。在我们的研究中，我们旨在评估和比较CAE的这些预测参数。
我们进行了一项研究，分析因急性冠状动脉综合征接受血管造影的患者。根据是否存在CAE将患者分为两组。在评估自变量时，Cox回归分析考虑了CAE的显著预测因素。采用ROC曲线分析评估这些变量对CAE的预测能力，并比较曲线下面积（AUC）值。
纳入研究的2279例患者平均随访498天。5.35%的患者存在冠状动脉扩张。低密度脂蛋白/高密度脂蛋白比值和淋巴细胞计数独立预测CAE。
在我们的研究中，观察到低密度脂蛋白/高密度脂蛋白（LDL/HDL）比值和淋巴细胞减少独立预测CAE。从标准血液检测中获得的LDL/HDL比值可作为一种经济有效且简单的方法来预测CAE，对治疗规划、预后和患者随访有重要贡献。
