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登革出血热合并完全性房室传导阻滞:一例报告

Dengue Hemorrhagic Fever Complicated by Complete Atrioventricular Block: A Case Report.

作者信息

Abshir Tanad, Al Hassani Ali, Al Hassani Zaid, Saleem Aqeel

机构信息

Internal Medicine, Sheikh Tahnoon Bin Mohammed Medical City, Al Ain, ARE.

Infectious Disease, Sheikh Tahnoon Bin Mohammed Medical City, Al Ain, ARE.

出版信息

Cureus. 2025 May 22;17(5):e84611. doi: 10.7759/cureus.84611. eCollection 2025 May.

Abstract

Dengue virus (DENV) infection is a common mosquito-borne disease with a broad clinical spectrum ranging from mild febrile illness to severe manifestations such as dengue haemorrhagic fever (DHF) and dengue shock syndrome. While hematologic and vascular complications are well-documented, cardiac involvement, such as conduction abnormalities, is less well-known but potentially fatal. A 53-year-old male with a five-day history of fever, fatigue, and dizziness presented in hemodynamic instability with severe bradycardia and hypotension. An ECG showed complete heart block, requiring the urgent insertion of a temporary pacemaker. Transthoracic echocardiogram demonstrated mildly reduced left ventricular systolic function (left ventricular ejection fraction = 45%). Laboratory investigations revealed thrombocytopenia with a platelet count of 109 × 10⁹/L. The patient had no known allergic conditions. Based on the clinical presentation and high index of suspicion, a dengue test was performed, confirming the infection through positive IgM serology and reverse transcriptase-polymerase chain reaction, which identified the DENV-2 serotype. Despite supportive care, the patient did not recover a normal cardiac rhythm and ultimately required a permanent pacemaker. This case highlights the potential for complete heart block as a severe complication of DHF.

摘要

登革病毒(DENV)感染是一种常见的蚊媒疾病,临床谱广泛,从轻度发热性疾病到严重表现,如登革出血热(DHF)和登革休克综合征。虽然血液学和血管并发症已有充分记录,但心脏受累,如传导异常,却鲜为人知但可能致命。一名53岁男性,有发热、疲劳和头晕5天病史,出现血流动力学不稳定,伴有严重心动过缓和低血压。心电图显示完全性心脏传导阻滞,需要紧急插入临时起搏器。经胸超声心动图显示左心室收缩功能轻度降低(左心室射血分数 = 45%)。实验室检查显示血小板减少,血小板计数为109×10⁹/L。患者无已知过敏情况。基于临床表现和高度怀疑,进行了登革热检测,通过阳性IgM血清学和逆转录聚合酶链反应确认感染,确定为DENV-2血清型。尽管给予了支持治疗,患者仍未恢复正常心律,最终需要植入永久性起搏器。该病例突出了完全性心脏传导阻滞作为DHF严重并发症的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f673/12181977/66b33300ba7e/cureus-0017-00000084611-i01.jpg

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