Amiri Sohrab, Khan Moien A B
Spiritual Health Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Health and Wellness Research Group, Department of Family Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, UAE.
Gen Psychiatr. 2025 Jun 20;38(3):e102016. doi: 10.1136/gpsych-2024-102016. eCollection 2025.
Mental disorders rank among the leading contributors to the global disease burden, with depressive disorders being among the most prevalent.
The objective of this study is to examine the prevalence, incidence and years lived with disability (YLDs) associated with depressive disorders, particularly major depressive disorder and dysthymia, in Iran from 1990 to 2021. To achieve this, the research focused on analysing these metrics across various dimensions, including temporal trends, sex differences, age categories and subnational regions.
The data used in this study are sourced directly from the Institute for Health Metrics and Evaluation, ensuring that the information is both authoritative and reliable. All-age count estimates and age-standardised rates (per 100 000) were calculated for prevalence, incidence and YLDs. The disease burden indicators were analysed for the period spanning from 1990 to 2021, stratified by sex, age and location. The percentage change between 1990 and 2021 was also documented. The 95% uncertainty interval (UI) was reported for each of the reported estimates.
The prevalence of depressive disorders in Iran demonstrated a notable upward trend from 1990 to 2021, with the rate of growth being particularly pronounced within the country. The age-standardised prevalence rate per 100 000 individuals for depressive disorders in Iran was 5609 (95% UI 4810 to 6488). By 2021, the number of depression cases in Iran reached 5.2 million, which is approximately 2.37 times the figure reported in 1990. The prevalence of depressive disorders was notably higher among females compared with males. The age-standardised prevalence rate per 100 000 individuals for males was 4184 (95% UI 3545 to 4929). For females, this figure was significantly greater, reaching 7077 (95% UI 6115 to 8172). Out of the total reported cases of depressive disorders in Iran, 3.2 million were observed in females, while males accounted for 2 million cases.
The findings highlighted the considerable impact of depressive disorders in Iran, both nationally and regionally, while also revealing variations across sex and age groups. Given the shifts in the demographic structure and the growing burden of these disorders, it is essential to prioritise screening initiatives, education programmes and strategies aimed at enhancing mental health awareness and ensuring improved access to mental health services in health policy planning.
精神障碍是全球疾病负担的主要促成因素之一，抑郁症是最常见的精神障碍类型。
本研究旨在调查1990年至2021年伊朗抑郁症（尤其是重度抑郁症和心境恶劣障碍）的患病率、发病率和伤残调整生命年（YLDs）。为实现这一目标，研究重点分析了这些指标在不同维度上的情况，包括时间趋势、性别差异、年龄类别和国家以下区域。
本研究使用的数据直接来源于健康指标与评估研究所，确保信息具有权威性和可靠性。计算了全年龄段的患病率、发病率和YLDs的计数估计值以及年龄标准化率（每10万人）。分析了1990年至2021年期间按性别、年龄和地点分层的疾病负担指标。还记录了1990年至2021年期间的百分比变化。报告的每个估计值都给出了95%的不确定性区间（UI）。
1990年至2021年期间，伊朗抑郁症的患病率呈显著上升趋势，在国内增长率尤为明显。伊朗每10万人中抑郁症的年龄标准化患病率为5609（95% UI 4810至6488）。到2021年，伊朗抑郁症病例数达到520万，约为1990年报告数字的2.37倍。抑郁症的患病率在女性中明显高于男性。男性每10万人的年龄标准化患病率为4184（95% UI 3545至4929）。女性的这一数字显著更高，达到7077（95% UI 611
