Mannias Giada, Scano Alessandra, Cabriolu Cristiana, Sini Franca, Hudson Sarah, Ennas Guido
Department of Chemical and Geological Sciences, University of Cagliari, SS 554 Bivio Per Sestu, 09042 Monserrato (CA), Italy.
National Interuniversity Consortium of Materials Science and Technology (INSTM), Via Giuseppe Giusti 9, 50121 Firenze, Italy.
ACS Omega. 2025 Jun 4;10(23):25039-25050. doi: 10.1021/acsomega.5c02865. eCollection 2025 Jun 17.
A low-cost enzyme-mimic iron-(III) trimesate MOF, prepared by a novel and green mechanochemical synthetic protocol, is used for the excellent colorimetric detection of hydrogen peroxide (HO). The developed iron-(III) trimesate MOF, solvent-free mechanochemically synthesized under mild conditions and in a very short time (from 6 to 60 min), is an exciting potential candidate for HO detection, avoiding the immobilization of additional peroxidase enzymes. The influence of pH, temperature, catalyst concentration, and incubation time on iron-(III) trimesate MOF peroxidase-mimic activity was investigated, showing a lower limit of detection (0.24 μM) and a wider linear range (7.5-75 μM) than other peroxidase-like inorganic materials typically used for colorimetric sensing. The superior catalytic properties of our material with respect to the current literature can be ascribed to the presence of defects in the MOF structure due to the milling synthesis process.
一种通过新颖的绿色机械化学合成方法制备的低成本类酶铁（III）均苯三甲酸金属有机框架（MOF），用于出色的比色法检测过氧化氢（HO）。所开发的铁（III）均苯三甲酸MOF在温和条件下且在极短时间内（6至60分钟）通过无溶剂机械化学合成，是用于HO检测的一个令人兴奋的潜在候选物，避免了额外过氧化物酶的固定化。研究了pH、温度、催化剂浓度和孵育时间对铁（III）均苯三甲酸MOF过氧化物酶模拟活性的影响，结果表明其检测下限（0.24 μM）比通常用于比色传感的其他类过氧化物酶无机材料更低，线性范围（7.5 - 75 μM）更宽。相对于当前文献，我们材料的优异催化性能可归因于研磨合成过程导致的MOF结构中存在缺陷。
