Boninsegna A, Pradella M, Scutari G, Vassanelli P, Perissinotto A
Horm Metab Res. 1985 Aug;17(8):399-401. doi: 10.1055/s-2007-1013557.
The effect of a prolonged fast was studied in surgically portocaval shunted (PCS) rats. This shunt excludes the liver from the direct effect of pancreatic and enteric hormones, thus facilitating the study of the biochemical and metabolic effects of these hormones. In portocaval shunted rats, liver glycogen was lower than that of control rats, and remained unaffected during fasting. No remarkable difference was observed in blood glucose, plasma and liver free fatty acids and blood ketone bodies. Among blood nitrogen compounds, total protein, alanine and urea did not show any significant variation, while, in PCS rats, the initial low levels of creatinine resulted in an increase after fast. Skeletal muscle protein decreased only slightly in control rats, while their loss was remarkable in PCS rats. The possibility of a differential activation of gluconeogenesis and glycogenolysis in control and PCS rats is discussed.
在接受外科门腔分流术（PCS）的大鼠中研究了长期禁食的影响。这种分流使肝脏免受胰腺和肠道激素的直接作用，从而便于研究这些激素的生化和代谢作用。在门腔分流的大鼠中，肝糖原低于对照大鼠，并且在禁食期间保持不变。血糖、血浆和肝脏游离脂肪酸以及血酮体未观察到显著差异。在血氮化合物中，总蛋白、丙氨酸和尿素没有任何显著变化，而在PCS大鼠中，最初较低的肌酐水平在禁食后有所升高。讨论了对照大鼠和PCS大鼠中糖异生和糖原分解差异激活的可能性。
