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禁食时间对成年大鼠呼吸商以及游离脂肪酸、葡萄糖和尿素血浆水平的影响。

Effects of fasting time on the respiratory quotient and plasma levels of free fatty acids, glucose and urea in adult rats.

作者信息

Uliasz-Poniewierska M

出版信息

Acta Physiol Pol. 1982 Jul-Aug;33(4):317-26.

PMID:7184315
Abstract

The experiments were carried out on 96 male Wistar rats weighing 320-460 g kept either in a warm room (24-26 degrees C) or cold room (15 degrees C). After 0, 3, 6, 12 and 24 hours of fasting determinations were done of: metabolic rate (MR), respiratory quotient (RQ), plasma levels of free fatty acids (FFA), glucose (G) and urea (U), and the glycogen levels in the liver and muscles, as well as total urinary nitrogen excretion in fasted and fed rats. The obtained results showed that changes in the G level in the blood of fasted rats were almost as good an index of changes in carbohydrate metabolism as RQ changes. Changes of U level in the blood of fasted rats reflected fairly well the changes in the amount of catabolized proteins, while FFA level changes were a less accurate index since increased lipolysis may precede considerably increased oxidation of fats.

摘要

实验在96只体重320 - 460克的雄性Wistar大鼠身上进行,这些大鼠饲养在温暖房间(24 - 26摄氏度)或寒冷房间(15摄氏度)。在禁食0、3、6、12和24小时后,测定了以下指标:代谢率(MR)、呼吸商(RQ)、血浆游离脂肪酸(FFA)、葡萄糖(G)和尿素(U)水平,以及肝脏和肌肉中的糖原水平,还有禁食和进食大鼠的尿氮总排泄量。所得结果表明,禁食大鼠血液中G水平的变化几乎与RQ变化一样,是碳水化合物代谢变化的良好指标。禁食大鼠血液中U水平的变化相当好地反映了分解代谢蛋白质数量的变化,而FFA水平变化则是一个不太准确的指标,因为脂肪分解增加可能在脂肪氧化显著增加之前就已发生。

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