Khan Yousaf, Mukhtiar Anila, Sarfraz Hina, Khan Shoaib, Hussain Rafaqat, Naeem Mujeeb Ul, Sattar Abdul, Aziz Tariq, Panezai Zia Ur Rehman, Albekairi Thamer H, Jabbir Farwa
Department of Chemistry, 66715 COMSATS University Islamabad , Campus 45550, Islamabad, Pakistan.
Department of Chemistry, Abbottabad University of Science and Technology, Abbottabad 22500, Pakistan.
Z Naturforsch C J Biosci. 2025 Jun 24. doi: 10.1515/znc-2024-0244.
The present investigation explained various heterocyclic moieties particularly the thiazolidinone scaffold () which were synthesized from benzothiazole as promising anti-Alzheimer agent. In this, we have unveiled the synthetic path for generation of thiazolidinone scaffolds which was initiated benzothiazole having 2-amine moiety. These synthesized scaffolds were then inveterate through several analytical techniques including high-resolution electron impact mass spectrometry (HREI-MS), proton nuclear magnetic resonance (H NMR), and carbon-13 nuclear magnetic resonance (C NMR). The anti-Alzheimer potential of these compounds was evaluated through molecular docking studies to examine their interactions with target proteins. Additionally, ADMET analysis was performed to assess drug-likeness and pharmacokinetic properties. Among the synthesized analogs, scaffold- emerged as the most promising inhibitor compared to other derivatives in the series. This study highlights the potential of thiazolidinone derivatives in the development of novel anti-Alzheimer drugs and underscores the need for further optimization to enhance their therapeutic efficacy.
本研究解释了各种杂环部分，特别是由苯并噻唑合成的噻唑烷酮支架（），其作为有前景的抗阿尔茨海默病药物。在此，我们揭示了噻唑烷酮支架的合成途径，该途径以具有2-胺部分的苯并噻唑开始。然后通过包括高分辨率电子轰击质谱（HREI-MS）、质子核磁共振（H NMR）和碳-13核磁共振（C NMR）在内的几种分析技术对这些合成支架进行确认。通过分子对接研究评估这些化合物的抗阿尔茨海默病潜力，以检查它们与靶蛋白的相互作用。此外，进行了ADMET分析以评估药物相似性和药代动力学性质。在合成的类似物中，与该系列中的其他衍生物相比，支架-成为最有前景的抑制剂。本研究突出了噻唑烷酮衍生物在开发新型抗阿尔茨海默病药物方面的潜力，并强调需要进一步优化以提高其治疗效果。
