Mohammed Reham A, Kamel Ahmed S, Hindam Merhan O, El-Dessouki Ahmed M, Hamouda Hend A, Ramadan Nehal M, Mohamed Sarah S, El-Shiekh Riham A, Kamel Nada M
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.
Department of Pharmacy Practice, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, Egypt.
Inflammopharmacology. 2025 Jun 23. doi: 10.1007/s10787-025-01811-0.
Phenylethanoid glycosides are naturally occurring water-soluble molecules with remarkable biological characteristics that are abundant throughout the plant world. Acteoside (AC) is a phenylethanoid glycoside that was first discovered in mullein, but is also found in various other plant species. It has four moieties: caffeic acid, glucose, rhamnose, and phenylethyl alcohol. AC is an important bioactive natural compound isolated from many plant species. Extracts from different plant species, including Barleria prionitis, B. lupulina, Rhinacanthus nasutus, Orthosiphon aristatus, and Nicoteba betonica, have high quantities of AC. AC is hydrophilic in nature, and it has several bioactivities such as anti-inflammatory, antibacterial, antiviral, antioxidant, antidiabetic, neuroprotective, cardioprotective, anticancer, and wound-healing properties. In this review, we discuss its prominent pharmacological properties. The findings provide valuable insights for future research on AC which exhibit promising anti-inflammatory activities.
苯乙醇苷是天然存在的水溶性分子，具有显著的生物学特性，在整个植物界都很丰富。松果菊苷（AC）是一种苯乙醇苷，最初是在毛蕊花中发现的，但也存在于其他各种植物物种中。它有四个部分：咖啡酸、葡萄糖、鼠李糖和苯乙醇。AC是从许多植物物种中分离出来的一种重要的生物活性天然化合物。来自不同植物物种的提取物，包括刺粉花、淡黄巴戟天、鼻花、猫须草和烟草，都含有大量的AC。AC本质上是亲水性的，它具有多种生物活性，如抗炎、抗菌、抗病毒、抗氧化、抗糖尿病、神经保护、心脏保护、抗癌和伤口愈合特性。在这篇综述中，我们讨论了它突出的药理特性。这些发现为未来对具有有前景的抗炎活性的AC的研究提供了有价值的见解。
