念珠菌溶素的宿主靶点。
Host targets of candidalysin.
作者信息
Lin Jianfeng, Filler Scott G
机构信息
Division of Infectious Diseases, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America.
David Geffen School of Medicine at University of California Los Angeles, Los Angels, California, United States of America.
出版信息
PLoS Pathog. 2025 Jun 23;21(6):e1013284. doi: 10.1371/journal.ppat.1013284. eCollection 2025 Jun.
Candida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C. albicans hyphae secrete candidalysin, a cytolytic peptide toxin that damages host cells and activates immune responses. Candidalysin plays a key role in both pathogenicity and commensalism. In this Pearl, we review the host targets of candidalysin and how they modulate the interaction of C. albicans with the host.
白色念珠菌是人类微生物群的正常组成部分，也是对人类普遍存在的威胁。这种真菌会引发多种疾病，从浅表皮肤和黏膜念珠菌病到危及生命的播散性念珠菌病。白色念珠菌的菌丝会分泌念珠溶素，这是一种细胞溶解性肽毒素，可损害宿主细胞并激活免疫反应。念珠溶素在致病性和共生关系中都起着关键作用。在这篇精粹文章中，我们综述了念珠溶素的宿主靶点以及它们如何调节白色念珠菌与宿主之间的相互作用。
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