Wang Mengxue, Chen Yun, Zhang Yue, Li Kai, Wang Sen, Li Lei, Wang Cili, Li Pinglin
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China; Laboratory of Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Laboratory of Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.
Fitoterapia. 2025 Sep;185:106709. doi: 10.1016/j.fitote.2025.106709. Epub 2025 Jun 21.
Three new azaphilone derivatives, namely talavaritones A-C (1-3), together with seven known compounds (4-10) were isolated from the soft coral-derived fungus Talaromyces variabilis. The structures of these compounds were elucidated by comprehensive spectral analyses, DP4+ probability analyses, together with experimental and calculated ECD spectra. Structurally, compound 1 is the first reported example of 1, 2-seco-azaphilone. Moreover, compounds 7-10 exhibited cytotoxic activities against several human cancer cell lines with IC values ranging from 4.3 to 29.2 μM.
从软珊瑚来源的真菌多变篮状菌中分离得到了三种新的氮杂蒽酮衍生物，即塔拉瓦里酮A - C（1 - 3），以及七种已知化合物（4 - 10）。通过综合光谱分析、DP4 +概率分析以及实验和计算的电子圆二色光谱对这些化合物的结构进行了阐明。在结构上，化合物1是首次报道的1, 2 - 开环氮杂蒽酮实例。此外，化合物7 - 10对几种人类癌细胞系表现出细胞毒性活性，IC值范围为4.3至29.2 μM。
