深海来源真菌 HDN151398 中新型含谷氨酰胺的吖啶酮生物碱。
New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus HDN151398.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
出版信息
Mar Drugs. 2019 Apr 28;17(5):253. doi: 10.3390/md17050253.
Three new azaphilone alkaloids containing glutamine residues, namely -glutarylchaetoviridins A-C (-), together with two related compounds ( and ) were isolated from the extract of HDN151398, a fungus isolated from a deep-sea sediment sample collected in South China Sea. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data and chemical analysis. -glutarylchaetoviridins A-C (-) represent the first class of chaetoviridins characterized by embedded glutamate residues. Amino acids incubation experiments produced five azaphilone laden different amino acids residues (-) which indicated that this method can enhanced the structural diversity of this strain by culturing with amino acids. Cytotoxicity of the isolated compounds were evaluated against a panel of human cancer cell lines.
从南海深海沉积物样本中分离得到的真菌 HDN151398 的提取物中，分离得到了三种含有谷氨酰胺残基的新的氮杂菲酮生物碱：-谷氨酰基查托维丁 A-C（-），以及两种相关化合物（和）。基于广泛的 1D 和 2D NMR 以及 HRESIMS 光谱数据和化学分析，阐明了它们的结构。-谷氨酰基查托维丁 A-C（-）代表了第一类以嵌入谷氨酸残基为特征的查托维丁。氨基酸孵育实验产生了五种含有不同氨基酸残基的氮杂菲酮（-），这表明通过与氨基酸共培养，这种方法可以增强该菌株的结构多样性。对分离得到的化合物进行了针对一系列人类癌细胞系的细胞毒性评估。
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