Teodoro Lara I, Ovsyannikova Inna G, Grill Diane E, Poland Gregory A, Kennedy Richard B
Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Int J Infect Dis. 2025 Sep;158:107964. doi: 10.1016/j.ijid.2025.107964. Epub 2025 Jun 21.
Respiratory syncytial virus (RSV) infection may cause serious illness and mortality in older adults (≥65 years). This study aimed to assess the seroprevalence of anti-RSV IgG antibodies in adults from a United States cohort and compare antibody levels among individuals with a history of recent RSV vaccination or infection.
A total of 475 subjects (ages 27-99) were randomly selected from the Mayo Clinic Biobank's residual sera repository (2022-2023). Samples were tested for anti-RSV IgG using an enzyme-linked immunosorbent assay (ELISA). Additional cohorts included individuals with documented RSV infection (n = 40) or recent RSV vaccination (n = 71).
Among the seroprevalence cohort, 83.8% tested RSV IgG positive against RSV-A whole virus antigen. Males had significantly higher antibody titers than females (P < 0.001), and antibody titers increased post-RSV season (p = 0.02). Compared to the general cohort, RSV-seropositivity rates were higher in recently diagnosed (97.5%) and vaccinated (95.8%) individuals.
This study demonstrates a high seroprevalence of RSV-A IgG in adults, with variations across sex and seasonality, and corroborates waning immunity following RSV infection. Recent infection or vaccination significantly boosts antibody levels, reinforcing the importance of continued surveillance of RSV immunity.
呼吸道合胞病毒（RSV）感染可能导致老年人（≥65岁）出现严重疾病和死亡。本研究旨在评估美国一个队列中成年人抗RSV IgG抗体的血清流行率，并比较近期有RSV疫苗接种或感染史的个体之间的抗体水平。
从梅奥诊所生物样本库的剩余血清储存库（2022 - 2023年）中随机选取475名受试者（年龄27 - 99岁）。使用酶联免疫吸附测定（ELISA）检测样本中的抗RSV IgG。其他队列包括有记录的RSV感染个体（n = 40）或近期RSV疫苗接种个体（n = 71）。
在血清流行率队列中，83.8%的人针对RSV - A全病毒抗原检测出RSV IgG阳性。男性的抗体滴度显著高于女性（P < 0.001），且RSV季节过后抗体滴度升高（p = 0.02）。与一般队列相比，近期确诊（97.5%）和接种疫苗（95.8%）的个体中RSV血清阳性率更高。
本研究表明成年人中RSV - A IgG的血清流行率较高，存在性别和季节性差异，并证实了RSV感染后免疫力的下降。近期感染或接种疫苗显著提高了抗体水平，强化了持续监测RSV免疫力的重要性。
