Schena F P, Pastore A, Manno C, Varvara B
Int J Artif Organs. 1985 Jul;8 Suppl 2:3-6.
In an uncontrolled clinical trial the effects of plasma-exchange (PE) on the capacity of the serum to solubilize circulating immune complexes were studied in patients with active systemic lupus erythematosus. Four patients were treated with immunosuppressive therapy alone, while others were also treated by PE over a period of four to seven weeks. Plasma was replaced by fresh frozen plasma in the final part of each procedure. All patients showed evidence of clinical improvement at the time of treatment. Furthermore, PE was demonstrated to reduce drastically the number of relapses. An improvement of the capacity of solubilize immune complexes in vitro associated with a persistent fall in the levels of the circulating immune complexes was observed in patients treated with PE. This suggests that fresh frozen plasma improves the clearance of immune complexes and reduces the frequency of relapses. In our experience, clinical improvement and/or resolution of the symptoms seems to be related to the decrease in serum immune complex levels, while clinical relapses seem to parallel the behaviour of complement-mediated solubilization.
在一项非对照临床试验中，研究了血浆置换（PE）对活动性系统性红斑狼疮患者血清溶解循环免疫复合物能力的影响。4例患者仅接受免疫抑制治疗，而其他患者还在4至7周的时间内接受了PE治疗。在每个治疗过程的最后阶段，用新鲜冷冻血浆替代血浆。所有患者在治疗时均有临床改善的迹象。此外，PE被证明可大幅减少复发次数。在接受PE治疗的患者中，观察到体外溶解免疫复合物的能力有所改善，同时循环免疫复合物水平持续下降。这表明新鲜冷冻血浆可改善免疫复合物的清除并降低复发频率。根据我们的经验，临床改善和/或症状缓解似乎与血清免疫复合物水平的降低有关，而临床复发似乎与补体介导的溶解行为平行。
