Teissandier Dorian, Gillet Charlotte, Chaumont Soline, Mercier Sylvie, Lefebvre Marie, Lasri Wiame, Djama Guedi Aïcha, Taillandier Marie, Hanet Nathalie, Jimenez Liliana, Demaretz Laetitia, Morand Christine, Manach Claudine
Université Clermont Auvergne, INRAE, UNH, F-63000 Clermont-Ferrand, France.
Emergency Department, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Food Funct. 2025 Jul 14;16(14):5791-5808. doi: 10.1039/d4fo06326k.
(Poly)phenols represent a large class of bioactive compounds present in our diet. An increasing number of epidemiological, clinical and pre-clinical studies are demonstrating the beneficial effects of (poly)phenols on various health parameters, parlicularly in relation to the prevention of cardiometabolic diseases. However, fully understanding their potential in preventive nutrition requires significant improvements in the assessment of individuals' exposure to a variety of (poly)phenols. One of the current limitations is the use of standard Food Frequency Questionnaires (FFQs) that are not specifically designed for that purpose and as a consequence lack precision and accuracy for the assessment of (poly)phenol intake. We developed the FFQ PhenolQuest, specially designed to assess with a high level of details the dietary intake of 120 (poly)phenols belonging to all main families, in populations following a European-style diet. It includes 188 foods with a number of additional variations ( = 75). Special effort was made to optimize the questionnaire's design and usability. In particular, the consumption frequency options were expanded compared to the standard FFQ and tailored to the different food groups. An application test conducted on a French population panel of 110 subjects demonstrated PhenolQuest's ability to capture the diversity of (poly)phenol source consumption patterns. PhenolQuest is shared in integrality for free use and further validation by the community. This article presents the challenges and strategies used for its development, as well as its scope of use.
（多）酚类是我们饮食中存在的一大类生物活性化合物。越来越多的流行病学、临床和临床前研究表明，（多）酚类对各种健康参数具有有益影响，特别是在预防心脏代谢疾病方面。然而，要充分了解它们在预防性营养中的潜力，需要在评估个体对各种（多）酚类的暴露方面有显著改进。当前的一个局限性是使用标准食物频率问卷（FFQ），这些问卷并非专门为此目的设计，因此在评估（多）酚类摄入量时缺乏精度和准确性。我们开发了酚类摄入量问卷（PhenolQuest），专门用于详细评估遵循欧式饮食的人群中属于所有主要类别的120种（多）酚类的饮食摄入量。它包括188种食物以及一些额外的变体（=75种）。我们特别努力优化了问卷的设计和可用性。特别是，与标准FFQ相比，消费频率选项有所扩展，并针对不同食物组进行了调整。在一个由110名受试者组成的法国人群小组上进行的应用测试表明，酚类摄入量问卷（PhenolQuest）能够捕捉（多）酚类来源消费模式的多样性。酚类摄入量问卷（PhenolQuest）完整共享以供社区免费使用和进一步验证。本文介绍了其开发过程中面临的挑战和采用的策略，以及其使用范围。
