Fu Chengfeng, Zhang Lixia, Luo Jing, Zhang Yingying
Respiratory and Critical Care Medicine, The Second People's Hospital of Banan District, Chongqing, China.
Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Front Nutr. 2025 Jun 9;12:1471549. doi: 10.3389/fnut.2025.1471549. eCollection 2025.
Chronic obstructive pulmonary disease (COPD) is a long-lasting condition that significantly hinders respiratory function. Niacin, a crucial nutrient in the diet, is essential for maintaining general health. However, research on the effects of niacin on the mortality risk among individuals with COPD is sparse. Hence, this study aims to investigate the relationship between dietary niacin intake and mortality within this specific cohort of individuals.
A total of 3,674 self-reported COPD individuals from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included in this study. The Cox proportional hazards model assessed the association between niacin intake and all-cause/cardiovascular disease (CVD) mortality. Kaplan-Meier curves illustrated survival based on niacin intake. Subgroup and sensitivity analyses were conducted to assess the robustness of the results. During an average follow-up period of 8.3 years, 1,085 all-cause deaths occurred, including 323 CVD-related deaths. A 10 mg/day niacin increase was associated with a 12% lower all-cause and 13% lower CVD mortality risk. Compared to the low dietary niacin intake group, the high intake group had a hazard ratio (HR) of 0.67 (95% CI: 0.56-0.82, < 0.001) for all-cause mortality and 0.53 (95% CI: 0.37-0.77, = 0.001) for CVD mortality. Kaplan-Meier survival curves indicated higher survival rates in the high-niacin group.
A higher dietary intake of niacin was associated with lower all-cause and CVD mortality among individuals with COPD.
慢性阻塞性肺疾病（COPD）是一种长期疾病，严重妨碍呼吸功能。烟酸是饮食中的一种关键营养素，对维持总体健康至关重要。然而，关于烟酸对COPD患者死亡风险影响的研究较少。因此，本研究旨在调查这一特定人群中膳食烟酸摄入量与死亡率之间的关系。
本研究纳入了1999 - 2018年美国国家健康与营养检查调查（NHANES）中3674名自我报告患有COPD的个体。Cox比例风险模型评估了烟酸摄入量与全因/心血管疾病（CVD）死亡率之间的关联。Kaplan - Meier曲线说明了基于烟酸摄入量的生存率。进行了亚组分析和敏感性分析以评估结果的稳健性。在平均8.3年的随访期内，发生了1085例全因死亡，其中包括323例与CVD相关的死亡。烟酸摄入量每天增加10毫克与全因死亡率降低12%和CVD死亡率降低13%相关。与低膳食烟酸摄入量组相比，高摄入量组的全因死亡率风险比（HR）为0.67（95%CI：0.56 - 0.82，P<0.001），CVD死亡率风险比为0.53（95%CI：0.37 - 0.77，P = 0.001）。Kaplan - Meier生存曲线表明高烟酸组的生存率更高。
COPD患者中较高的膳食烟酸摄入量与较低的全因死亡率和CVD死亡率相关。
