Zhou Zhengxi, Yao Xiaotian
Department of Urology, Ningbo Mingzhou Hospital, Zhejiang, China.
The Division of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Front Nutr. 2024 Nov 21;11:1435297. doi: 10.3389/fnut.2024.1435297. eCollection 2024.
The relationship between niacin and the risk of mortality in chronic kidney disease (CKD) patients remains unclear. This study aims to investigate the potential correlation.
This cohort study utilized data from the 2003-2018 National Health and Nutrition Examination Survey (NHANES). The study included 6,110 patients with CKD aged 18 years or older. Weighted Cox proportional hazards models and restricted cubic splines (RCS) were employed to estimate hazard ratios for all-cause mortality and cardiovascular disease (CVD) mortality. Niacin intake was estimated using the 24 h dietary recall method, based on the type and amount of food consumed. All-cause mortality and cardiac mortality rates were determined using National Death Index (NDI) mortality data (as of 31 December 2018).
The median niacin intake was 20.89 mg/day, with an interquartile range of 15.67-27.99 mg/day. During the follow-up period (median of 87 months), there were 1,984 all-cause deaths, including 714 CVD deaths. Compared with low niacin intake, the multivariate-adjusted hazard ratio for dietary intake of 22 mg or higher was 0.71 (95% CI, 0.57-0.88) for all-cause mortality and 0.75 (95% CI, 0.57, 0.98) for CVD mortality.
Dietary niacin intake is associated with a reduction in all-cause and cardiac mortality among CKD patients.
烟酸与慢性肾脏病（CKD）患者死亡率之间的关系仍不明确。本研究旨在调查其潜在相关性。
这项队列研究使用了2003 - 2018年美国国家健康与营养检查调查（NHANES）的数据。该研究纳入了6110名18岁及以上的CKD患者。采用加权Cox比例风险模型和受限立方样条（RCS）来估计全因死亡率和心血管疾病（CVD）死亡率的风险比。基于所摄入食物的类型和数量，采用24小时膳食回顾法估算烟酸摄入量。使用国家死亡指数（NDI）死亡率数据（截至2018年12月31日）确定全因死亡率和心脏死亡率。
烟酸摄入量的中位数为20.89毫克/天，四分位间距为15.67 - 27.99毫克/天。在随访期间（中位数为87个月），有1984例全因死亡，其中包括714例CVD死亡。与低烟酸摄入量相比，膳食摄入量为22毫克或更高时，全因死亡率的多变量调整风险比为0.71（95%CI，0.57 - 0.88），CVD死亡率的多变量调整风险比为0.75（95%CI，0.57，0.98）。
膳食烟酸摄入量与CKD患者全因死亡率和心脏死亡率的降低有关。
