Zurowska A M, Wrzolkowa T, Uszycka-Karcz M
Int J Pediatr Nephrol. 1985 Jul-Sep;6(3):183-8.
36 children with Henoch-Schönlein nephritis had their renal biopsy specimens studied by light and electron microscopic and immunofluorescence antibody techniques. Though no pathognomic changes were found the histological picture was characteristic. The severity of histological changes correlated well with the clinical manifestation and disease persistence. IMF studies showed characteristic mesangial IgA staining. The most prominent ultrastructural feature was segmental mesangial and subendothelial deposits with basement membrane changes. The amount of deposits was a good exponent of disease activity-children with few deposits recovering shortly. In spite of long duration, the outcome after an average 4 year follow-up was good, the majority of children having improved and renal insufficiency developing rarely. Renal biopsy is essential for an estimation of severity of renal disease and enables prognosis of disease persistence and long term outlook.
对36例过敏性紫癜性肾炎患儿的肾活检标本进行了光镜、电镜及免疫荧光抗体技术研究。虽未发现特异性改变，但组织学表现具有特征性。组织学改变的严重程度与临床表现及疾病持续时间密切相关。免疫荧光研究显示系膜区有特征性IgA染色。最显著的超微结构特征是节段性系膜及内皮下沉积物伴基底膜改变。沉积物的量是疾病活动度的良好指标——沉积物少的患儿恢复较快。尽管病程较长，但平均4年随访后的结果良好，大多数患儿病情改善，很少发生肾功能不全。肾活检对于评估肾脏疾病的严重程度至关重要，有助于判断疾病持续情况及长期预后。
