Maury C P, Wegelius O
Int J Tissue React. 1985;7(5):405-7.
Serum amyloid A protein (SAA) and C-reactive protein (CRP) are acute-phase reactants synthesized by the liver. A close relationship was found between SAA and CRP concentrations in various rheumatic diseases (rs = 0.74 to 0.83). The serum concentration of these proteins reflected the activity of the rheumatic inflammation in a sensitive way. In secondary amyloidosis, persistently high SAA and CRP levels correlated closely with the progression of the renal amyloid manifestations. The findings show that measurements of SAA and CRP concentrations are valuable in assessing disease activity and the effect of therapy in rheumatic diseases, as well as in the assessment of the prognosis in secondary amyloidosis. Therapeutic measures that decrease SAA levels may reduce amyloid formation.
血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）是由肝脏合成的急性期反应物。在各种风湿性疾病中，SAA和CRP浓度之间存在密切关系（rs = 0.74至0.83）。这些蛋白质的血清浓度以敏感的方式反映了风湿性炎症的活动情况。在继发性淀粉样变性中，持续高的SAA和CRP水平与肾脏淀粉样表现的进展密切相关。研究结果表明，测量SAA和CRP浓度在评估风湿性疾病的疾病活动度和治疗效果以及评估继发性淀粉样变性的预后方面具有重要价值。降低SAA水平的治疗措施可能会减少淀粉样蛋白的形成。
