多次低剂量链脲佐菌素诱导的糖尿病作为研究人类自身免疫性糖尿病的模型。
Multiple low dose streptozotocin-induced diabetes as a model for studying autoimmune diabetes in humans.
作者信息
Koprivica Ivan, Stanisavljević Suzana, Mićanović Dragica, Stojanović Ivana, Miljković Đorđe
机构信息
Department of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
出版信息
Animal Model Exp Med. 2025 Sep;8(9):1539-1551. doi: 10.1002/ame2.70050. Epub 2025 Jun 24.
The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 diabetes (T1D) in humans. Spontaneous animal models of T1D greatly contribute to our understanding of the disease pathogenesis and therapeutic options. Amongst many disease models, a significant proportion of T1D research is performed on multiple low dose streptozotocin induced diabetes in experimental animals, in parallel. Here, we discuss advantages of this model for contemporary T1D research. Additionally, challenges and perspectives for further improvement of the model are presented.
针对胰腺β细胞的自身免疫反应是人类1型糖尿病（T1D）最关键的致病过程。T1D的自发动物模型极大地有助于我们理解该疾病的发病机制和治疗选择。在众多疾病模型中，相当一部分T1D研究是同时在实验动物中采用多次低剂量链脲佐菌素诱导糖尿病的方法进行的。在此，我们讨论该模型在当代T1D研究中的优势。此外，还提出了进一步改进该模型所面临的挑战和前景。
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