Livingston R C
J Assoc Off Anal Chem. 1985 Sep-Oct;68(5):966-7.
Antibiotics are used extensively in food-producing animals to maintain optimal health and promote growth. The use of these drugs has the potential to leave drug-related residues such as parent drug and metabolites in meat, milk, and eggs. For those drugs that require a withholding period to ensure that residues in the food products are below established tolerances, methods of analysis are required. The majority of approved antibiotics are assayed by microbiological methods. Although these methods are suitable for screening for drug residues, they often lack the specificity and precision required of regulatory methods. Present requirements for regulatory methods have resulted in the submission of physical-chemical methods in support of New Animal Drug Applications for antibiotics.
抗生素在食用动物中被广泛使用，以维持最佳健康状态并促进生长。使用这些药物有可能在肉、奶和蛋中留下与药物相关的残留物，如母体药物和代谢物。对于那些需要停药期以确保食品中的残留物低于既定耐受量的药物，需要分析方法。大多数已批准的抗生素通过微生物学方法进行检测。虽然这些方法适用于药物残留的筛查，但它们往往缺乏监管方法所需的特异性和精密度。目前对监管方法的要求导致了支持抗生素新动物药品申请的物理化学方法的提交。
